Amino Acid Transporters and Glutamine Metabolism in Breast Cancer
Amino acid transporters are membrane transport proteins, most of which are members of the solute carrier families. Amino acids are essential for the survival of all types of cells, including tumor cells, which have an increased demand for nutrients to facilitate proliferation and cancer progression....
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doaj-9173ef83cdc94e4a945ffe087d003fb02020-11-24T22:30:23ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-03-0119390710.3390/ijms19030907ijms19030907Amino Acid Transporters and Glutamine Metabolism in Breast CancerYoon Jin Cha0Eun-Sol Kim1Ja Seung Koo2Department of Pathology, Yonsei University College of Medicine, Seoul, 03722, KoreaDepartment of Pathology, Yonsei University College of Medicine, Seoul, 03722, KoreaDepartment of Pathology, Yonsei University College of Medicine, Seoul, 03722, KoreaAmino acid transporters are membrane transport proteins, most of which are members of the solute carrier families. Amino acids are essential for the survival of all types of cells, including tumor cells, which have an increased demand for nutrients to facilitate proliferation and cancer progression. Breast cancer is the most common malignancy in women worldwide and is still associated with high mortality rates, despite improved treatment strategies. Recent studies have demonstrated that the amino acid metabolic pathway is altered in breast cancer and that amino acid transporters affect tumor growth and progression. In breast cancer, glutamine is one of the key nutrients, and glutamine metabolism is closely related to the amino acid transporters. In this review, we focus on amino acid transporters and their roles in breast cancer. We also highlight the different subsets of upregulated amino acid transporters in breast cancer and discuss their potential applications as treatment targets, cancer imaging tracers, and drug delivery components. Glutamine metabolism as well as its regulation and therapeutic implication in breast cancer are also discussed.http://www.mdpi.com/1422-0067/19/3/907amino acid transportershuman pathologybreast cancertransport mechanism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoon Jin Cha Eun-Sol Kim Ja Seung Koo |
spellingShingle |
Yoon Jin Cha Eun-Sol Kim Ja Seung Koo Amino Acid Transporters and Glutamine Metabolism in Breast Cancer International Journal of Molecular Sciences amino acid transporters human pathology breast cancer transport mechanism |
author_facet |
Yoon Jin Cha Eun-Sol Kim Ja Seung Koo |
author_sort |
Yoon Jin Cha |
title |
Amino Acid Transporters and Glutamine Metabolism in Breast Cancer |
title_short |
Amino Acid Transporters and Glutamine Metabolism in Breast Cancer |
title_full |
Amino Acid Transporters and Glutamine Metabolism in Breast Cancer |
title_fullStr |
Amino Acid Transporters and Glutamine Metabolism in Breast Cancer |
title_full_unstemmed |
Amino Acid Transporters and Glutamine Metabolism in Breast Cancer |
title_sort |
amino acid transporters and glutamine metabolism in breast cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-03-01 |
description |
Amino acid transporters are membrane transport proteins, most of which are members of the solute carrier families. Amino acids are essential for the survival of all types of cells, including tumor cells, which have an increased demand for nutrients to facilitate proliferation and cancer progression. Breast cancer is the most common malignancy in women worldwide and is still associated with high mortality rates, despite improved treatment strategies. Recent studies have demonstrated that the amino acid metabolic pathway is altered in breast cancer and that amino acid transporters affect tumor growth and progression. In breast cancer, glutamine is one of the key nutrients, and glutamine metabolism is closely related to the amino acid transporters. In this review, we focus on amino acid transporters and their roles in breast cancer. We also highlight the different subsets of upregulated amino acid transporters in breast cancer and discuss their potential applications as treatment targets, cancer imaging tracers, and drug delivery components. Glutamine metabolism as well as its regulation and therapeutic implication in breast cancer are also discussed. |
topic |
amino acid transporters human pathology breast cancer transport mechanism |
url |
http://www.mdpi.com/1422-0067/19/3/907 |
work_keys_str_mv |
AT yoonjincha aminoacidtransportersandglutaminemetabolisminbreastcancer AT eunsolkim aminoacidtransportersandglutaminemetabolisminbreastcancer AT jaseungkoo aminoacidtransportersandglutaminemetabolisminbreastcancer |
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