Topological Reorganization of the Default Mode Network in Severe Male Obstructive Sleep Apnea
Impaired spontaneous regional activity and altered topology of the brain network have been observed in obstructive sleep apnea (OSA). However, the mechanisms of disrupted functional connectivity (FC) and topological reorganization of the default mode network (DMN) in patients with OSA remain largely...
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doaj-91801d37d11e4fcbbbf2f6676492af002020-11-24T22:13:49ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-06-01910.3389/fneur.2018.00363339295Topological Reorganization of the Default Mode Network in Severe Male Obstructive Sleep ApneaLiting Chen0Xiaole Fan1Haijun Li2Chenglong Ye3Honghui Yu4Honghan Gong5Xianjun Zeng6Dechang Peng7Liping Yan8Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Cardiology, People’s Hospital of Jiangxi Province, Nanchang, Jiangxi, ChinaImpaired spontaneous regional activity and altered topology of the brain network have been observed in obstructive sleep apnea (OSA). However, the mechanisms of disrupted functional connectivity (FC) and topological reorganization of the default mode network (DMN) in patients with OSA remain largely unknown. We explored whether the FC is altered within the DMN and examined topological changes occur in the DMN in patients with OSA using a graph theory analysis of resting-state functional magnetic resonance imaging data and evaluated the relationship between neuroimaging measures and clinical variables. Resting-state data were obtained from 46 male patients with untreated severe OSA and 46 male good sleepers (GSs). We specifically selected 20 DMN subregions to construct the DMN architecture. The disrupted FC and topological properties of the DMN in patients with OSA were characterized using graph theory. The OSA group showed significantly decreased FC of the anterior–posterior DMN and within the posterior DMN, and also showed increased FC within the DMN. The DMN exhibited small-world topology in both OSA and GS groups. Compared to GSs, patients with OSA showed a decreased clustering coefficient (Cp) and local efficiency, and decreased nodal centralities in the left posterior cingulate cortex and dorsal medial prefrontal cortex, and increased nodal centralities in the ventral medial prefrontal cortex and the right parahippocampal cortex. Finally, the abnormal DMN FC was significantly related to Cp, path length, global efficiency, and Montreal cognitive assessment score. OSA showed disrupted FC within the DMN, which may have contributed to the observed topological reorganization. These findings may provide further evidence of cognitive deficits in patients with OSA.https://www.frontiersin.org/article/10.3389/fneur.2018.00363/fullobstructive sleep apneadefault mode networkcognitive functionresting-state functional magnetic resonance imaginggraph theory |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liting Chen Xiaole Fan Haijun Li Chenglong Ye Honghui Yu Honghan Gong Xianjun Zeng Dechang Peng Liping Yan |
spellingShingle |
Liting Chen Xiaole Fan Haijun Li Chenglong Ye Honghui Yu Honghan Gong Xianjun Zeng Dechang Peng Liping Yan Topological Reorganization of the Default Mode Network in Severe Male Obstructive Sleep Apnea Frontiers in Neurology obstructive sleep apnea default mode network cognitive function resting-state functional magnetic resonance imaging graph theory |
author_facet |
Liting Chen Xiaole Fan Haijun Li Chenglong Ye Honghui Yu Honghan Gong Xianjun Zeng Dechang Peng Liping Yan |
author_sort |
Liting Chen |
title |
Topological Reorganization of the Default Mode Network in Severe Male Obstructive Sleep Apnea |
title_short |
Topological Reorganization of the Default Mode Network in Severe Male Obstructive Sleep Apnea |
title_full |
Topological Reorganization of the Default Mode Network in Severe Male Obstructive Sleep Apnea |
title_fullStr |
Topological Reorganization of the Default Mode Network in Severe Male Obstructive Sleep Apnea |
title_full_unstemmed |
Topological Reorganization of the Default Mode Network in Severe Male Obstructive Sleep Apnea |
title_sort |
topological reorganization of the default mode network in severe male obstructive sleep apnea |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2018-06-01 |
description |
Impaired spontaneous regional activity and altered topology of the brain network have been observed in obstructive sleep apnea (OSA). However, the mechanisms of disrupted functional connectivity (FC) and topological reorganization of the default mode network (DMN) in patients with OSA remain largely unknown. We explored whether the FC is altered within the DMN and examined topological changes occur in the DMN in patients with OSA using a graph theory analysis of resting-state functional magnetic resonance imaging data and evaluated the relationship between neuroimaging measures and clinical variables. Resting-state data were obtained from 46 male patients with untreated severe OSA and 46 male good sleepers (GSs). We specifically selected 20 DMN subregions to construct the DMN architecture. The disrupted FC and topological properties of the DMN in patients with OSA were characterized using graph theory. The OSA group showed significantly decreased FC of the anterior–posterior DMN and within the posterior DMN, and also showed increased FC within the DMN. The DMN exhibited small-world topology in both OSA and GS groups. Compared to GSs, patients with OSA showed a decreased clustering coefficient (Cp) and local efficiency, and decreased nodal centralities in the left posterior cingulate cortex and dorsal medial prefrontal cortex, and increased nodal centralities in the ventral medial prefrontal cortex and the right parahippocampal cortex. Finally, the abnormal DMN FC was significantly related to Cp, path length, global efficiency, and Montreal cognitive assessment score. OSA showed disrupted FC within the DMN, which may have contributed to the observed topological reorganization. These findings may provide further evidence of cognitive deficits in patients with OSA. |
topic |
obstructive sleep apnea default mode network cognitive function resting-state functional magnetic resonance imaging graph theory |
url |
https://www.frontiersin.org/article/10.3389/fneur.2018.00363/full |
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