ToTem: a tool for variant calling pipeline optimization

ToTem: a tool for variant calling pipeline optimization

Abstract Background High-throughput bioinformatics analyses of next generation sequencing (NGS) data often require challenging pipeline optimization. The key problem is choosing appropriate tools and selecting the best parameters for optimal precision and recall. Results Here we introduce ToTem, a t...

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Bibliographic Details
Main Authors: Nikola Tom, Ondrej Tom, Jitka Malcikova, Sarka Pavlova, Blanka Kubesova, Tobias Rausch, Miroslav Kolarik, Vladimir Benes, Vojtech Bystry, Sarka Pospisilova
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Bioinformatics
Subjects:
Variant calling
Benchmarking
Next generation sequencing
Parameter optimization
Online Access:http://link.springer.com/article/10.1186/s12859-018-2227-x

Internet

http://link.springer.com/article/10.1186/s12859-018-2227-x

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