Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs

Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs

Abstract Background Autophagy has emerged as a key mechanism in the survival and function of T and B lymphocytes, and its activation was involved in apoptosis resistance in rheumatoid arthritis (RA). To investigate whether the relationship between autophagy and apoptosis may impact the response to t...

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Bibliographic Details
Main Authors: M. Vomero, V. Manganelli, C. Barbati, T. Colasanti, A. Capozzi, A. Finucci, F. R. Spinelli, F. Ceccarelli, C. Perricone, S. Truglia, S. Morrone, R. Maggio, R. Misasi, M. Bombardieri, M. Di Franco, F. Conti, M. Sorice, G. Valesini, C. Alessandri
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Arthritis Research & Therapy
Subjects:
Autophagy
Apoptosis
Rheumatoid arthritis
TNFα
TNF inhibitors
Online Access:http://link.springer.com/article/10.1186/s13075-019-1818-x

Internet

http://link.springer.com/article/10.1186/s13075-019-1818-x

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