New vaccines on the horizon
Vaccines are considered to be one of the greatest public health achievements of the last century. As a result of widespread vaccine use, the smallpox virus has been completely eradicated and the incidence of other diseases such as polio, measles, tetanus and diphtheria has been drastically reduced....
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2019-01-01
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doaj-919c0eb8a89347988b6c7fcfec998a382021-03-22T20:07:34ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672019-01-0169638540510.5937/arhfarm1906385A0004-19631906385ANew vaccines on the horizonArsenović-Ranin Nevena0https://orcid.org/0000-0002-8052-8969Univerzitet u Beogradu, Farmaceutski fakultet, Katedra za mikrobiologiju i imunologiju, SerbiaVaccines are considered to be one of the greatest public health achievements of the last century. As a result of widespread vaccine use, the smallpox virus has been completely eradicated and the incidence of other diseases such as polio, measles, tetanus and diphtheria has been drastically reduced. Current licensed vaccines, predominantly composed of either live attenuated or killed pathogens, pathogen subunits, owe their success to their ability to elicit neutralizing antibodies against pathogens. On the other side, cell-mediated immunity, which plays a central role in elimination of intracellular pathogens (which in most cases leads to chronic infections) is much more difficult to obtain using current vaccines. Currently, numerous vector and nucleic acid (DNA and mRNA)-based prophylactic vaccines, capable of inducing substantial vaccine-specific T cell responses, are investigated in preclinical and clinical studies, with promising results. This review focuses the background of vector and nucleic acid-based vaccines, their strengths and weaknesses and safety issues.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631906385A.pdfvaccine typesvector vaccinesdna vaccinesmrna vaccines |
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DOAJ |
language |
srp |
format |
Article |
sources |
DOAJ |
author |
Arsenović-Ranin Nevena |
spellingShingle |
Arsenović-Ranin Nevena New vaccines on the horizon Arhiv za farmaciju vaccine types vector vaccines dna vaccines mrna vaccines |
author_facet |
Arsenović-Ranin Nevena |
author_sort |
Arsenović-Ranin Nevena |
title |
New vaccines on the horizon |
title_short |
New vaccines on the horizon |
title_full |
New vaccines on the horizon |
title_fullStr |
New vaccines on the horizon |
title_full_unstemmed |
New vaccines on the horizon |
title_sort |
new vaccines on the horizon |
publisher |
Pharmaceutical Association of Serbia, Belgrade, Serbia |
series |
Arhiv za farmaciju |
issn |
0004-1963 2217-8767 |
publishDate |
2019-01-01 |
description |
Vaccines are considered to be one of the greatest public health achievements of the last century. As a result of widespread vaccine use, the smallpox virus has been completely eradicated and the incidence of other diseases such as polio, measles, tetanus and diphtheria has been drastically reduced. Current licensed vaccines, predominantly composed of either live attenuated or killed pathogens, pathogen subunits, owe their success to their ability to elicit neutralizing antibodies against pathogens. On the other side, cell-mediated immunity, which plays a central role in elimination of intracellular pathogens (which in most cases leads to chronic infections) is much more difficult to obtain using current vaccines. Currently, numerous vector and nucleic acid (DNA and mRNA)-based prophylactic vaccines, capable of inducing substantial vaccine-specific T cell responses, are investigated in preclinical and clinical studies, with promising results. This review focuses the background of vector and nucleic acid-based vaccines, their strengths and weaknesses and safety issues. |
topic |
vaccine types vector vaccines dna vaccines mrna vaccines |
url |
https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631906385A.pdf |
work_keys_str_mv |
AT arsenovicraninnevena newvaccinesonthehorizon |
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