Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil

Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil

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In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom...

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Bibliographic Details
Main Authors: Elisa Maria Beirão, Juvencio Jose Duailibe Furtado, Raquel Girardello, Heli Ferreira Filho, Ana Cristina Gales
Format: Article
Language:English
Published: Elsevier
Series:Brazilian Journal of Infectious Diseases
Subjects:
Klebsiella pneumonia
KPC
hospital infection
carbapenemase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100013&lng=en&tlng=en
Description
Summary:In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.
ISSN:1678-4391

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