Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil

Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil

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In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom...

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Main Authors: Elisa Maria Beirão, Juvencio Jose Duailibe Furtado, Raquel Girardello, Heli Ferreira Filho, Ana Cristina Gales
Format: Article
Language:English
Published: Elsevier
Series:Brazilian Journal of Infectious Diseases
Subjects:
Klebsiella pneumonia
KPC
hospital infection
carbapenemase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100013&lng=en&tlng=en
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spelling doaj-919fcc375bfc4faea3b6ca1f9ad1952b2020-11-25T03:05:56ZengElsevierBrazilian Journal of Infectious Diseases1678-4391151697310.1590/S1413-86702011000100013S1413-86702011000100013Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in BrazilElisa Maria Beirão0Juvencio Jose Duailibe Furtado1Raquel Girardello2Heli Ferreira Filho3Ana Cristina Gales4Hospital HeliópolisHospital HeliópolisUniversidade Federal de São PauloHospital HeliópolisUniversidade Federal de São PauloIn 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100013&lng=en&tlng=enKlebsiella pneumoniaKPChospital infectioncarbapenemase
collection DOAJ
language English
format Article
sources DOAJ
author Elisa Maria Beirão
Juvencio Jose Duailibe Furtado
Raquel Girardello
Heli Ferreira Filho
Ana Cristina Gales
spellingShingle Elisa Maria Beirão
Juvencio Jose Duailibe Furtado
Raquel Girardello
Heli Ferreira Filho
Ana Cristina Gales
Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil
Brazilian Journal of Infectious Diseases
Klebsiella pneumonia
KPC
hospital infection
carbapenemase
author_facet Elisa Maria Beirão
Juvencio Jose Duailibe Furtado
Raquel Girardello
Heli Ferreira Filho
Ana Cristina Gales
author_sort Elisa Maria Beirão
title Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil
title_short Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil
title_full Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil
title_fullStr Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil
title_full_unstemmed Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil
title_sort clinical and microbiological characterization of kpc-producing klebsiella pneumoniae infections in brazil
publisher Elsevier
series Brazilian Journal of Infectious Diseases
issn 1678-4391
description In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.
topic Klebsiella pneumonia
KPC
hospital infection
carbapenemase
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100013&lng=en&tlng=en
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