Osteoporosis and Hemophilia
Hemophilia — an hereditary coagulopathy, in which the process of anticoagulation is due to genetic deficiency and decreased procoagulant activity of FVIII (IX). The most difficult manifestation of hemophilia is the development of chronic hemophilic arthropathy, the severity of which is directly depe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2012-08-01
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| Series: | Bolʹ, Sustavy, Pozvonočnik |
| Subjects: | |
| Online Access: | http://pjs.zaslavsky.com.ua/article/view/82644 |
| Summary: | Hemophilia — an hereditary coagulopathy, in which the process of anticoagulation is due to genetic deficiency and decreased procoagulant activity of FVIII (IX). The most difficult manifestation of hemophilia is the development of chronic hemophilic arthropathy, the severity of which is directly dependent on the level of the scarce factor and the adequacy of replacement therapy. The clinical course of hemophilic arthropathy begins with acute hemarthrosis, is at the stage of chronic villous synovitis and ultimately leads to osteoarthritis deformans, fibrous ankylosis, and the development of secondary periarticular osteoporosis. The aim of our study was to identify risk factors for osteopenia and osteoporosis in metaepiphysis bones forming the joint, as well as trace the dependence of reduction in bone mineral density from the level of deficient FVIII (IX) in patients with hemophilia. |
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| ISSN: | 2224-1507 2307-1133 |