Osteoporosis and Hemophilia
Hemophilia — an hereditary coagulopathy, in which the process of anticoagulation is due to genetic deficiency and decreased procoagulant activity of FVIII (IX). The most difficult manifestation of hemophilia is the development of chronic hemophilic arthropathy, the severity of which is directly depe...
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Zaslavsky O.Yu.
2012-08-01
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Online Access: | http://pjs.zaslavsky.com.ua/article/view/82644 |
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doaj-91a1c737b4484c669bbb37fbca2e74842020-11-24T22:49:08ZengZaslavsky O.Yu.Bolʹ, Sustavy, Pozvonočnik2224-15072307-11332012-08-0103.07263010.22141/2224-1507.3.07.2012.8264482644Osteoporosis and HemophiliaA.S. Kalis0N.R. Kech1L.Ye. Freifeld2State Institution «Institute of Blood Pathology and Transfusion Medicine of National Academy of Medical Sciences of Ukraine»; State Institution «Institute of Hereditary Disease of National Academy of Medical Sciences of Ukraine», LvivState Institution «Institute of Blood Pathology and Transfusion Medicine of National Academy of Medical Sciences of Ukraine»; State Institution «Institute of Hereditary Disease of National Academy of Medical Sciences of Ukraine», LvivState Institution «Institute of Blood Pathology and Transfusion Medicine of National Academy of Medical Sciences of Ukraine»; State Institution «Institute of Hereditary Disease of National Academy of Medical Sciences of Ukraine», LvivHemophilia — an hereditary coagulopathy, in which the process of anticoagulation is due to genetic deficiency and decreased procoagulant activity of FVIII (IX). The most difficult manifestation of hemophilia is the development of chronic hemophilic arthropathy, the severity of which is directly dependent on the level of the scarce factor and the adequacy of replacement therapy. The clinical course of hemophilic arthropathy begins with acute hemarthrosis, is at the stage of chronic villous synovitis and ultimately leads to osteoarthritis deformans, fibrous ankylosis, and the development of secondary periarticular osteoporosis. The aim of our study was to identify risk factors for osteopenia and osteoporosis in metaepiphysis bones forming the joint, as well as trace the dependence of reduction in bone mineral density from the level of deficient FVIII (IX) in patients with hemophilia.http://pjs.zaslavsky.com.ua/article/view/82644hemophiliadensitometryhemophilic arthropathysecondary osteoporosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A.S. Kalis N.R. Kech L.Ye. Freifeld |
spellingShingle |
A.S. Kalis N.R. Kech L.Ye. Freifeld Osteoporosis and Hemophilia Bolʹ, Sustavy, Pozvonočnik hemophilia densitometry hemophilic arthropathy secondary osteoporosis |
author_facet |
A.S. Kalis N.R. Kech L.Ye. Freifeld |
author_sort |
A.S. Kalis |
title |
Osteoporosis and Hemophilia |
title_short |
Osteoporosis and Hemophilia |
title_full |
Osteoporosis and Hemophilia |
title_fullStr |
Osteoporosis and Hemophilia |
title_full_unstemmed |
Osteoporosis and Hemophilia |
title_sort |
osteoporosis and hemophilia |
publisher |
Zaslavsky O.Yu. |
series |
Bolʹ, Sustavy, Pozvonočnik |
issn |
2224-1507 2307-1133 |
publishDate |
2012-08-01 |
description |
Hemophilia — an hereditary coagulopathy, in which the process of anticoagulation is due to genetic deficiency and decreased procoagulant activity of FVIII (IX). The most difficult manifestation of hemophilia is the development of chronic hemophilic arthropathy, the severity of which is directly dependent on the level of the scarce factor and the adequacy of replacement therapy. The clinical course of hemophilic arthropathy begins with acute hemarthrosis, is at the stage of chronic villous synovitis and ultimately leads to osteoarthritis deformans, fibrous ankylosis, and the development of secondary periarticular osteoporosis. The aim of our study was to identify risk factors for osteopenia and osteoporosis in metaepiphysis bones forming the joint, as well as trace the dependence of reduction in bone mineral density from the level of deficient FVIII (IX) in patients with hemophilia. |
topic |
hemophilia densitometry hemophilic arthropathy secondary osteoporosis |
url |
http://pjs.zaslavsky.com.ua/article/view/82644 |
work_keys_str_mv |
AT askalis osteoporosisandhemophilia AT nrkech osteoporosisandhemophilia AT lyefreifeld osteoporosisandhemophilia |
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