Intersession reliability of fMRI activation for heat pain and motor tasks
As the practice of conducting longitudinal fMRI studies to assess mechanisms of pain-reducing interventions becomes more common, there is a great need to assess the test–retest reliability of the pain-related BOLD fMRI signal across repeated sessions. This study quantitatively evaluated the reliabi...
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doaj-91a34e4c9ff74ee298f297124e88435a2020-11-25T00:19:56ZengElsevierNeuroImage: Clinical2213-15822014-01-015C30932110.1016/j.nicl.2014.07.005Intersession reliability of fMRI activation for heat pain and motor tasksRaimi L. Quiton0Michael L. Keaser1Jiachen Zhuo2Rao P. Gullapalli3Joel D. Greenspan4Department of Psychology, University of Maryland, Baltimore County, MD, USADepartment of Pain and Neural Sciences, School of Dentistry, and UM Center to Advance Chronic Pain Research, University of Maryland, Baltimore Country, MD, USADepartment of Diagnostic Radiology & Nuclear Medicine & Magnetic Resonance Research Center, School of Medicine, University of Maryland, Baltimore Country, MD, USADepartment of Diagnostic Radiology & Nuclear Medicine & Magnetic Resonance Research Center, School of Medicine, University of Maryland, Baltimore Country, MD, USADepartment of Pain and Neural Sciences, School of Dentistry, and UM Center to Advance Chronic Pain Research, University of Maryland, Baltimore Country, MD, USA As the practice of conducting longitudinal fMRI studies to assess mechanisms of pain-reducing interventions becomes more common, there is a great need to assess the test–retest reliability of the pain-related BOLD fMRI signal across repeated sessions. This study quantitatively evaluated the reliability of heat pain-related BOLD fMRI brain responses in healthy volunteers across 3 sessions conducted on separate days using two measures: (1) intraclass correlation coefficients (ICC) calculated based on signal amplitude and (2) spatial overlap. The ICC analysis of pain-related BOLD fMRI responses showed fair-to-moderate intersession reliability in brain areas regarded as part of the cortical pain network. Areas with the highest intersession reliability based on the ICC analysis included the anterior midcingulate cortex, anterior insula, and second somatosensory cortex. Areas with the lowest intersession reliability based on the ICC analysis also showed low spatial reliability; these regions included pregenual anterior cingulate cortex, primary somatosensory cortex, and posterior insula. Thus, this study found regional differences in pain-related BOLD fMRI response reliability, which may provide useful information to guide longitudinal pain studies. A simple motor task (finger-thumb opposition) was performed by the same subjects in the same sessions as the painful heat stimuli were delivered. Intersession reliability of fMRI activation in cortical motor areas was comparable to previously published findings for both spatial overlap and ICC measures, providing support for the validity of the analytical approach used to assess intersession reliability of pain-related fMRI activation. A secondary finding of this study is that the use of standard ICC alone as a measure of reliability may not be sufficient, as the underlying variance structure of an fMRI dataset can result in inappropriately high ICC values; a method to eliminate these false positive results was used in this study and is recommended for future studies of test–retest reliability. http://www.sciencedirect.com/science/article/pii/S2213158214000977Intraclass correlation coefficientReliability coefficientReproducibilityRepeatabilityAnterior insulaCingulate cortex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Raimi L. Quiton Michael L. Keaser Jiachen Zhuo Rao P. Gullapalli Joel D. Greenspan |
spellingShingle |
Raimi L. Quiton Michael L. Keaser Jiachen Zhuo Rao P. Gullapalli Joel D. Greenspan Intersession reliability of fMRI activation for heat pain and motor tasks NeuroImage: Clinical Intraclass correlation coefficient Reliability coefficient Reproducibility Repeatability Anterior insula Cingulate cortex |
author_facet |
Raimi L. Quiton Michael L. Keaser Jiachen Zhuo Rao P. Gullapalli Joel D. Greenspan |
author_sort |
Raimi L. Quiton |
title |
Intersession reliability of fMRI activation for heat pain and motor tasks |
title_short |
Intersession reliability of fMRI activation for heat pain and motor tasks |
title_full |
Intersession reliability of fMRI activation for heat pain and motor tasks |
title_fullStr |
Intersession reliability of fMRI activation for heat pain and motor tasks |
title_full_unstemmed |
Intersession reliability of fMRI activation for heat pain and motor tasks |
title_sort |
intersession reliability of fmri activation for heat pain and motor tasks |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2014-01-01 |
description |
As the practice of conducting longitudinal fMRI studies to assess mechanisms of pain-reducing interventions becomes more common, there is a great need to assess the test–retest reliability of the pain-related BOLD fMRI signal across repeated sessions. This study quantitatively evaluated the reliability of heat pain-related BOLD fMRI brain responses in healthy volunteers across 3 sessions conducted on separate days using two measures: (1) intraclass correlation coefficients (ICC) calculated based on signal amplitude and (2) spatial overlap. The ICC analysis of pain-related BOLD fMRI responses showed fair-to-moderate intersession reliability in brain areas regarded as part of the cortical pain network. Areas with the highest intersession reliability based on the ICC analysis included the anterior midcingulate cortex, anterior insula, and second somatosensory cortex. Areas with the lowest intersession reliability based on the ICC analysis also showed low spatial reliability; these regions included pregenual anterior cingulate cortex, primary somatosensory cortex, and posterior insula. Thus, this study found regional differences in pain-related BOLD fMRI response reliability, which may provide useful information to guide longitudinal pain studies. A simple motor task (finger-thumb opposition) was performed by the same subjects in the same sessions as the painful heat stimuli were delivered. Intersession reliability of fMRI activation in cortical motor areas was comparable to previously published findings for both spatial overlap and ICC measures, providing support for the validity of the analytical approach used to assess intersession reliability of pain-related fMRI activation. A secondary finding of this study is that the use of standard ICC alone as a measure of reliability may not be sufficient, as the underlying variance structure of an fMRI dataset can result in inappropriately high ICC values; a method to eliminate these false positive results was used in this study and is recommended for future studies of test–retest reliability.
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topic |
Intraclass correlation coefficient Reliability coefficient Reproducibility Repeatability Anterior insula Cingulate cortex |
url |
http://www.sciencedirect.com/science/article/pii/S2213158214000977 |
work_keys_str_mv |
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