Pharmacological and histopathological study of cyclophosphamide-induced hemorrhagic cystitis - comparison of the effects of dexamethasone and Mesna

Pharmacological and histopathological study of cyclophosphamide-induced hemorrhagic cystitis - comparison of the effects of dexamethasone and Mesna

Chemotherapy with oxazaphosphorines, such as cyclophosphamide (CYP), is often limited by unacceptable urotoxicity. Without uroprotection, hemorrhagic cystitis (HC) becomes dose-limiting. To compare the uroprotective efficacy of classical 2-mercaptoethanesulfonic acid (Mesna) treatment with dexametha...

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Bibliographic Details
Main Authors:	M.M. Morais, J.N. Belarmino-Filho, G.A.C. Brito, R.A. Ribeiro
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 1999-10-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	cyclophosphamide hemorrhagic cystitis dexamethasone Mesna
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001000006

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