Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety

Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety

O-GlcNAcase (OGA) is the only enzyme responsible for removing N-acetyl glucosamine (GlcNAc) attached to serine and threonine residues on proteins. This enzyme plays a key role in O-GlcNAc metabolism. However, the structural features of the sugar moiety recognized by human OGA (hOGA) remain unclear....

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Bibliographic Details
Main Authors: Shanshan Li, Jiajia Wang, Lanlan Zang, Hailiang Zhu, Jianshuang Guo, Jiabin Zhang, Liuqing Wen, Yi Chen, Yanhong Li, Xi Chen, Peng George Wang, Jing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Chemistry
Subjects:
O-GlcNAcylation
O-GlcNAcase
sugar moiety
GlcNAc derivatives
substrate specificity
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00646/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00646/full

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