The New Era of Three-Dimensional Histoarchitecture of the Human Endometrium
The histology of the endometrium has traditionally been established by observation of two-dimensional (2D) pathological sections. However, because human endometrial glands exhibit coiling and branching morphology, it is extremely difficult to obtain an entire image of the glands by 2D observation. I...
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doaj-91b5c4b00ef74452960a2bc745f078d82021-08-26T13:57:44ZengMDPI AGJournal of Personalized Medicine2075-44262021-07-011171371310.3390/jpm11080713The New Era of Three-Dimensional Histoarchitecture of the Human EndometriumManako Yamaguchi0Kosuke Yoshihara1Nozomi Yachida2Kazuaki Suda3Ryo Tamura4Tatsuya Ishiguro5Takayuki Enomoto6Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, JapanDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, JapanDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, JapanDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, JapanDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, JapanDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, JapanDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, JapanThe histology of the endometrium has traditionally been established by observation of two-dimensional (2D) pathological sections. However, because human endometrial glands exhibit coiling and branching morphology, it is extremely difficult to obtain an entire image of the glands by 2D observation. In recent years, the development of three-dimensional (3D) reconstruction of serial pathological sections by computer and whole-mount imaging technology using tissue clearing methods with high-resolution fluorescence microscopy has enabled us to observe the 3D histoarchitecture of tissues. As a result, 3D imaging has revealed that human endometrial glands form a plexus network in the basalis, similar to the rhizome of grass, whereas mouse uterine glands are single branched tubular glands. This review summarizes the relevant literature on the 3D structure of mouse and human endometrium and discusses the significance of the rhizome structure in the human endometrium and the expected role of understanding the 3D tissue structure in future applications to systems biology.https://www.mdpi.com/2075-4426/11/8/713endometriumendometrial glandendometrial-related diseasethree-dimensional (3D)3D imagingtissue clearing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manako Yamaguchi Kosuke Yoshihara Nozomi Yachida Kazuaki Suda Ryo Tamura Tatsuya Ishiguro Takayuki Enomoto |
spellingShingle |
Manako Yamaguchi Kosuke Yoshihara Nozomi Yachida Kazuaki Suda Ryo Tamura Tatsuya Ishiguro Takayuki Enomoto The New Era of Three-Dimensional Histoarchitecture of the Human Endometrium Journal of Personalized Medicine endometrium endometrial gland endometrial-related disease three-dimensional (3D) 3D imaging tissue clearing |
author_facet |
Manako Yamaguchi Kosuke Yoshihara Nozomi Yachida Kazuaki Suda Ryo Tamura Tatsuya Ishiguro Takayuki Enomoto |
author_sort |
Manako Yamaguchi |
title |
The New Era of Three-Dimensional Histoarchitecture of the Human Endometrium |
title_short |
The New Era of Three-Dimensional Histoarchitecture of the Human Endometrium |
title_full |
The New Era of Three-Dimensional Histoarchitecture of the Human Endometrium |
title_fullStr |
The New Era of Three-Dimensional Histoarchitecture of the Human Endometrium |
title_full_unstemmed |
The New Era of Three-Dimensional Histoarchitecture of the Human Endometrium |
title_sort |
new era of three-dimensional histoarchitecture of the human endometrium |
publisher |
MDPI AG |
series |
Journal of Personalized Medicine |
issn |
2075-4426 |
publishDate |
2021-07-01 |
description |
The histology of the endometrium has traditionally been established by observation of two-dimensional (2D) pathological sections. However, because human endometrial glands exhibit coiling and branching morphology, it is extremely difficult to obtain an entire image of the glands by 2D observation. In recent years, the development of three-dimensional (3D) reconstruction of serial pathological sections by computer and whole-mount imaging technology using tissue clearing methods with high-resolution fluorescence microscopy has enabled us to observe the 3D histoarchitecture of tissues. As a result, 3D imaging has revealed that human endometrial glands form a plexus network in the basalis, similar to the rhizome of grass, whereas mouse uterine glands are single branched tubular glands. This review summarizes the relevant literature on the 3D structure of mouse and human endometrium and discusses the significance of the rhizome structure in the human endometrium and the expected role of understanding the 3D tissue structure in future applications to systems biology. |
topic |
endometrium endometrial gland endometrial-related disease three-dimensional (3D) 3D imaging tissue clearing |
url |
https://www.mdpi.com/2075-4426/11/8/713 |
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