Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers
<b> </b>Bisphenols, particularly bisphenol A (4,4′-(hexafluoroisopropylidene)-diphenol) (BPA), are suspected of inducing oxidative stress in humans, which may be associated with adverse health outcomes. We investigated the associations between exposure to bisphenols and biomarkers of oxi...
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doaj-91b7a739ea1446c792d2c0831554dc902020-11-25T03:27:45ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012020-05-01173609360910.3390/ijerph17103609Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the BiomarkersInger-Lise Steffensen0Hubert Dirven1Stephan Couderq2Arthur David3Shereen Cynthia D’Cruz4Mariana F Fernández5Vicente Mustieles6Andrea Rodríguez-Carillo7Tim Hofer8Department of Environmental Health, Section of Toxicology and Risk Assessment, Norwegian Institute of Public Health, PO Box 222 Skøyen, N-0213 Oslo, NorwayDepartment of Environmental Health, Section of Toxicology and Risk Assessment, Norwegian Institute of Public Health, PO Box 222 Skøyen, N-0213 Oslo, NorwayDépartment “Adaption du Vivant“, Physiologie moléculaire et adaptation, Muséum national d’Histoire naturelle, UMR 7221 MNHN/CNRS, 7 rue Cuvier, 75005 Paris, FranceUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR_S 1085, F-35000 Rennes, FranceUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR_S 1085, F-35000 Rennes, FranceDepartment of Radiology and Physical Medicine, and Center for Biomedical Research (CIBM), University of Granada, 18016 Granada, SpainDepartment of Radiology and Physical Medicine, and Center for Biomedical Research (CIBM), University of Granada, 18016 Granada, SpainDepartment of Radiology and Physical Medicine, and Center for Biomedical Research (CIBM), University of Granada, 18016 Granada, SpainDepartment of Environmental Health, Section of Toxicology and Risk Assessment, Norwegian Institute of Public Health, PO Box 222 Skøyen, N-0213 Oslo, Norway<b> </b>Bisphenols, particularly bisphenol A (4,4′-(hexafluoroisopropylidene)-diphenol) (BPA), are suspected of inducing oxidative stress in humans, which may be associated with adverse health outcomes. We investigated the associations between exposure to bisphenols and biomarkers of oxidative stress in human studies over the last 12 years (2008‒2019) related to six health endpoints and evaluated their suitability as effect biomarkers. <i>PubMed</i> database searches identified 27 relevant articles that were used for data extraction. In all studies, BPA exposure was reported, whereas some studies also reported other bisphenols. More than a dozen different biomarkers were measured. The most frequently measured biomarkers were 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-isoprostane) and malondialdehyde (MDA), which almost always were positively associated with BPA. Methodological issues were reported for MDA, mainly the need to handle samples with caution to avoid artefact formation and its measurements using a chromatographic step to distinguish it from similar aldehydes, making some of the MDA results less reliable. Urinary 8-OHdG and 8-isoprostane can be considered the most reliable biomarkers of oxidative stress associated with BPA exposure. Although none of the biomarkers are considered BPA- or organ-specific, the biomarkers can be assessed repeatedly and non-invasively in urine and could help to understand causal relationships.https://www.mdpi.com/1660-4601/17/10/3609adverse outcome pathway (AOP)analytical methodsantioxidantbisphenol F (BPF)bisphenol S (BPS)effect biomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Inger-Lise Steffensen Hubert Dirven Stephan Couderq Arthur David Shereen Cynthia D’Cruz Mariana F Fernández Vicente Mustieles Andrea Rodríguez-Carillo Tim Hofer |
spellingShingle |
Inger-Lise Steffensen Hubert Dirven Stephan Couderq Arthur David Shereen Cynthia D’Cruz Mariana F Fernández Vicente Mustieles Andrea Rodríguez-Carillo Tim Hofer Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers International Journal of Environmental Research and Public Health adverse outcome pathway (AOP) analytical methods antioxidant bisphenol F (BPF) bisphenol S (BPS) effect biomarker |
author_facet |
Inger-Lise Steffensen Hubert Dirven Stephan Couderq Arthur David Shereen Cynthia D’Cruz Mariana F Fernández Vicente Mustieles Andrea Rodríguez-Carillo Tim Hofer |
author_sort |
Inger-Lise Steffensen |
title |
Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers |
title_short |
Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers |
title_full |
Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers |
title_fullStr |
Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers |
title_full_unstemmed |
Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers |
title_sort |
bisphenols and oxidative stress biomarkers—associations found in human studies, evaluation of methods used, and strengths and weaknesses of the biomarkers |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2020-05-01 |
description |
<b> </b>Bisphenols, particularly bisphenol A (4,4′-(hexafluoroisopropylidene)-diphenol) (BPA), are suspected of inducing oxidative stress in humans, which may be associated with adverse health outcomes. We investigated the associations between exposure to bisphenols and biomarkers of oxidative stress in human studies over the last 12 years (2008‒2019) related to six health endpoints and evaluated their suitability as effect biomarkers. <i>PubMed</i> database searches identified 27 relevant articles that were used for data extraction. In all studies, BPA exposure was reported, whereas some studies also reported other bisphenols. More than a dozen different biomarkers were measured. The most frequently measured biomarkers were 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-isoprostane) and malondialdehyde (MDA), which almost always were positively associated with BPA. Methodological issues were reported for MDA, mainly the need to handle samples with caution to avoid artefact formation and its measurements using a chromatographic step to distinguish it from similar aldehydes, making some of the MDA results less reliable. Urinary 8-OHdG and 8-isoprostane can be considered the most reliable biomarkers of oxidative stress associated with BPA exposure. Although none of the biomarkers are considered BPA- or organ-specific, the biomarkers can be assessed repeatedly and non-invasively in urine and could help to understand causal relationships. |
topic |
adverse outcome pathway (AOP) analytical methods antioxidant bisphenol F (BPF) bisphenol S (BPS) effect biomarker |
url |
https://www.mdpi.com/1660-4601/17/10/3609 |
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