Structure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1+ Dendritic Cells

Structure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1+ Dendritic Cells

XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on cross-presenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of peptides or proteins into these DC. Therefore, we have functionally analyzed vari...

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Bibliographic Details
Main Authors: Arthur L. Kroczek, Evelyn Hartung, Stephanie Gurka, Martina Becker, Nele Reeg, Hans W. Mages, Sebastian Voigt, Christian Freund, Richard A. Kroczek
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
XCR1
XCL1
cross-presentation
antigen targeting
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02806/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02806/full

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