Antitumor Activities of Metal Oxide Nanoparticles
Nanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytotoxicity in cancer cells, but not in normal cells. In some cases, such anticancer activity has been demonstrated to hold for the nanoparticle...
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doaj-91cca37c8a744c199afa1d19827397362020-11-24T22:48:57ZengMDPI AGNanomaterials2079-49912015-06-01521004102110.3390/nano5021004nano5021004Antitumor Activities of Metal Oxide NanoparticlesMaria Pilar Vinardell0Montserrat Mitjans1Physiology Department, Faculty of Pharmacy, Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, SpainPhysiology Department, Faculty of Pharmacy, Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, SpainNanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytotoxicity in cancer cells, but not in normal cells. In some cases, such anticancer activity has been demonstrated to hold for the nanoparticle alone or in combination with different therapies, such as photocatalytic therapy or some anticancer drugs. Zinc oxide nanoparticles have been shown to have this activity alone or when loaded with an anticancer drug, such as doxorubicin. Other nanoparticles that show cytotoxic effects on cancer cells include cobalt oxide, iron oxide and copper oxide. The antitumor mechanism could work through the generation of reactive oxygen species or apoptosis and necrosis, among other possibilities. Here, we review the most significant antitumor results obtained with different metal oxide nanoparticles.http://www.mdpi.com/2079-4991/5/2/1004antitumorcancer therapymetal oxide nanoparticles in vitro in vivo |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Pilar Vinardell Montserrat Mitjans |
spellingShingle |
Maria Pilar Vinardell Montserrat Mitjans Antitumor Activities of Metal Oxide Nanoparticles Nanomaterials antitumor cancer therapy metal oxide nanoparticles in vitro in vivo |
author_facet |
Maria Pilar Vinardell Montserrat Mitjans |
author_sort |
Maria Pilar Vinardell |
title |
Antitumor Activities of Metal Oxide Nanoparticles |
title_short |
Antitumor Activities of Metal Oxide Nanoparticles |
title_full |
Antitumor Activities of Metal Oxide Nanoparticles |
title_fullStr |
Antitumor Activities of Metal Oxide Nanoparticles |
title_full_unstemmed |
Antitumor Activities of Metal Oxide Nanoparticles |
title_sort |
antitumor activities of metal oxide nanoparticles |
publisher |
MDPI AG |
series |
Nanomaterials |
issn |
2079-4991 |
publishDate |
2015-06-01 |
description |
Nanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytotoxicity in cancer cells, but not in normal cells. In some cases, such anticancer activity has been demonstrated to hold for the nanoparticle alone or in combination with different therapies, such as photocatalytic therapy or some anticancer drugs. Zinc oxide nanoparticles have been shown to have this activity alone or when loaded with an anticancer drug, such as doxorubicin. Other nanoparticles that show cytotoxic effects on cancer cells include cobalt oxide, iron oxide and copper oxide. The antitumor mechanism could work through the generation of reactive oxygen species or apoptosis and necrosis, among other possibilities. Here, we review the most significant antitumor results obtained with different metal oxide nanoparticles. |
topic |
antitumor cancer therapy metal oxide nanoparticles in vitro in vivo |
url |
http://www.mdpi.com/2079-4991/5/2/1004 |
work_keys_str_mv |
AT mariapilarvinardell antitumoractivitiesofmetaloxidenanoparticles AT montserratmitjans antitumoractivitiesofmetaloxidenanoparticles |
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1725677965181714432 |