Macroorchidism in a Patient with FSH-Secreting Pituitary Macroadenoma

Follicle-stimulating hormone-secreting pituitary macroadenoma (FSHoma) is a very rare and usually asymptomatic entity. FSHoma can clinically present as ovarian hyperstimulation syndrome in female patients, but symptoms and clinical signs are usually not observed in males. An increase in testicular v...

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Bibliographic Details
Main Authors: Eren Demirtaş, Hamiyet Yılmaz Yaşar;, Engin Güney, Mustafa Unubol, Gökhan Sargın, Nurcan Özdamar
Format: Article
Language:English
Published: Turkiye Klinikleri 2012-12-01
Series:Turkish Journal of Endocrinology and Metabolism
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Online Access:http://www.turkjem.org/eng/makale/801/77/Full-Text
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Summary:Follicle-stimulating hormone-secreting pituitary macroadenoma (FSHoma) is a very rare and usually asymptomatic entity. FSHoma can clinically present as ovarian hyperstimulation syndrome in female patients, but symptoms and clinical signs are usually not observed in males. An increase in testicular volume has been reported in male patients with FSHoma. In some male patients, the first finding may be macroorchidism. A 20-year-old male patient presented to our clinic due to enlarged testes (testicular volume: 45 cc). Scrotal ultrasonography showed macroorchidism. Tests required to determine the etiology of macroorchidism showed that the patient had an elevated FSH concentration. Macroadenoma was diagnosed based on pituitary magnetic resonance imaging. FSHoma was suspected and transsphenoidal resection was performed. Pathology test results indicated FSHoma. The present case shows that FSHoma is very rare and that it can present in association with macroorchidism in male patients. Turk Jem 2012; 16: 95-8
ISSN:1301-2193