Recent advances in chemistry and pharmacological aspects of 2-pyridone scaffolds

• Main Authors: Mostafa M.K. Amer, Maged A. Aziz, Wesam S. Shehab, Magda H. Abdellattif, Samar M. Mouneir
• Format: Article
• Language: English
• Published: Elsevier 2021-06-01
• Series: Journal of Saudi Chemical Society
• Subjects: 2-Pyridones synthesis and reactivity; Biological activity; Antibiotics; Antitumor agents
• Online Access: http://www.sciencedirect.com/science/article/pii/S1319610321000648

Background: The chemistry and applications of 2-pyridone structures have recently attracted a lot of attention due to their uses as synthetic intermediates and their biological importance. Furthermore, 2-pyridones are a different category of pharmacophores that exhibit several biological activities. Results: The 2-pyridones substrates are synthetically multilateral, where they can be used to synthesize a wide range of heterocyclic compounds and as a drug synthesis raw material. Therefore, it was the purpose of this review to evaluate the pharmacological properties of various substituted 2-pyridone systematically and collates these findings to be used as a guide for future structure–activity relationship and mode of action studies. Conclusion: Taken together, we demonstrate that the fused 2-pyridone is a versatile scaffold for biological applications.