Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?

Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?

Abstract The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact provirus Xq21.33 was recently identified in some West African people. We used PCR technology to search for the Xq21.33 provirus in DNA from Nigerian...

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Bibliographic Details
Main Authors: Mark H. Kaplan, Rafael Contreras-Galindo, Evelyn Jiagge, Sofia D. Merajver, Lisa Newman, Galya Bigman, Michael H. Dosik, Ganesh S. Palapattu, Javed Siddiqui, Arul M. Chinnaiyan, Sally Adebamowo, Clement Adebamowo
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Infectious Agents and Cancer
Subjects:
HERV-K
HERV-K HML-2
Xq21.33
Endogenous viruses
Gene conversion
Breast cancer
Online Access:http://link.springer.com/article/10.1186/s13027-020-00284-w

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