Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?
Abstract The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact provirus Xq21.33 was recently identified in some West African people. We used PCR technology to search for the Xq21.33 provirus in DNA from Nigerian...
Main Authors: | Mark H. Kaplan, Rafael Contreras-Galindo, Evelyn Jiagge, Sofia D. Merajver, Lisa Newman, Galya Bigman, Michael H. Dosik, Ganesh S. Palapattu, Javed Siddiqui, Arul M. Chinnaiyan, Sally Adebamowo, Clement Adebamowo |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-03-01
|
Series: | Infectious Agents and Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13027-020-00284-w |
Similar Items
-
HERV-K(HML7) Integrations in the Human Genome: Comprehensive Characterization and Comparative Analysis in Non-Human Primates
by: Nicole Grandi, et al.
Published: (2021-05-01) -
Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines
by: Witold Tatkiewicz, et al.
Published: (2020-02-01) -
CMV-Promoter Driven Codon-Optimized Expression Alters the Assembly Type and Morphology of a Reconstituted HERV-K(HML-2)
by: Oliver Hohn, et al.
Published: (2014-11-01) -
Comprehensive Analysis of HERV Transcriptome in HIV+ Cells: Absence of HML2 Activation and General Downregulation of Individual HERV Loci
by: Nicole Grandi, et al.
Published: (2020-04-01) -
Identification of a novel HERV-K(HML10): comprehensive characterization and comparative analysis in non-human primates provide insights about HML10 proviruses structure and diffusion
by: Nicole Grandi, et al.
Published: (2017-11-01)