Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case‐control study and meta‐analysis
Abstract Introduction Retinal structural changes in subjects with mild cognitive impairment (MCI) remain a subject of controversy. Methods We investigated the correlation between optical coherence tomography (OCT) of the retinal sublayers, including the retinal nerve fiber layer (RNFL), and cognitiv...
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doaj-91ffa60be97340f39c8fbb5a24727f6b2021-08-18T11:15:27ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292016-01-0141859310.1016/j.dadm.2016.07.004Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case‐control study and meta‐analysisBrianna Knoll0Joseph Simonett1Nicholas J. Volpe2Sina Farsiu3Mallory Ward4Alfred Rademaker5Sandra Weintraub6Amani A. Fawzi7Department of OphthalmologyFeinberg School of Medicine, Northwestern UniversityChicagoILUSADepartment of OphthalmologyFeinberg School of Medicine, Northwestern UniversityChicagoILUSADepartment of OphthalmologyFeinberg School of Medicine, Northwestern UniversityChicagoILUSADepartment of Biomedical Engineering and OphthalmologyDuke UniversityDurhamNCUSACognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern UniversityChicagoILUSADepartment of Preventive MedicineFeinberg School of Medicine, Northwestern UniversityChicagoILUSACognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern UniversityChicagoILUSADepartment of OphthalmologyFeinberg School of Medicine, Northwestern UniversityChicagoILUSAAbstract Introduction Retinal structural changes in subjects with mild cognitive impairment (MCI) remain a subject of controversy. Methods We investigated the correlation between optical coherence tomography (OCT) of the retinal sublayers, including the retinal nerve fiber layer (RNFL), and cognitive function in subjects with amnestic MCI and compared the OCT findings with matched controls. We also performed a meta‐analysis of the world literature using a random‐effects model. Results We found no statistically significant differences in OCT between amnestic MCI (aMCI) and controls. In aMCI subjects, we found an inverse relationship between RNFL thickness and two cognitive tests (delayed story recall and a word‐list learning test and the word‐list test). The meta‐analysis revealed a statistically significant decrease in RNFL thickness in MCI subjects. Discussion The inverse relationship between cognitive testing and RNFL thickness suggests that retinal involvement may include paradoxically increased thickness of the RNFL, which could suggest gliotic reactive changes.https://doi.org/10.1016/j.dadm.2016.07.004Alzheimer's diseaseMild cognitive impairmentRetinal nerve fiber layerOptical coherence tomographyBiomarkers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brianna Knoll Joseph Simonett Nicholas J. Volpe Sina Farsiu Mallory Ward Alfred Rademaker Sandra Weintraub Amani A. Fawzi |
spellingShingle |
Brianna Knoll Joseph Simonett Nicholas J. Volpe Sina Farsiu Mallory Ward Alfred Rademaker Sandra Weintraub Amani A. Fawzi Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case‐control study and meta‐analysis Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease Mild cognitive impairment Retinal nerve fiber layer Optical coherence tomography Biomarkers |
author_facet |
Brianna Knoll Joseph Simonett Nicholas J. Volpe Sina Farsiu Mallory Ward Alfred Rademaker Sandra Weintraub Amani A. Fawzi |
author_sort |
Brianna Knoll |
title |
Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case‐control study and meta‐analysis |
title_short |
Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case‐control study and meta‐analysis |
title_full |
Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case‐control study and meta‐analysis |
title_fullStr |
Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case‐control study and meta‐analysis |
title_full_unstemmed |
Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case‐control study and meta‐analysis |
title_sort |
retinal nerve fiber layer thickness in amnestic mild cognitive impairment: case‐control study and meta‐analysis |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2016-01-01 |
description |
Abstract Introduction Retinal structural changes in subjects with mild cognitive impairment (MCI) remain a subject of controversy. Methods We investigated the correlation between optical coherence tomography (OCT) of the retinal sublayers, including the retinal nerve fiber layer (RNFL), and cognitive function in subjects with amnestic MCI and compared the OCT findings with matched controls. We also performed a meta‐analysis of the world literature using a random‐effects model. Results We found no statistically significant differences in OCT between amnestic MCI (aMCI) and controls. In aMCI subjects, we found an inverse relationship between RNFL thickness and two cognitive tests (delayed story recall and a word‐list learning test and the word‐list test). The meta‐analysis revealed a statistically significant decrease in RNFL thickness in MCI subjects. Discussion The inverse relationship between cognitive testing and RNFL thickness suggests that retinal involvement may include paradoxically increased thickness of the RNFL, which could suggest gliotic reactive changes. |
topic |
Alzheimer's disease Mild cognitive impairment Retinal nerve fiber layer Optical coherence tomography Biomarkers |
url |
https://doi.org/10.1016/j.dadm.2016.07.004 |
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