Prognostic factors in patients with loco-regionally advanced gastric cancer
Abstract Background The aim of this study was to investigate epidemiologic and prognostic factors relevant to the treatment of loco-regionally advanced gastric cancer (GC). Methods Two hundred and fifty-five patients with GC were identified in Uppsala County between 2000 and 2009. Patient records we...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-09-01
|
Series: | World Journal of Surgical Oncology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12957-017-1243-z |
id |
doaj-9212da760ca046fc888ecd103a42b30a |
---|---|
record_format |
Article |
spelling |
doaj-9212da760ca046fc888ecd103a42b30a2020-11-24T21:11:58ZengBMCWorld Journal of Surgical Oncology1477-78192017-09-011511810.1186/s12957-017-1243-zPrognostic factors in patients with loco-regionally advanced gastric cancerBo Hultman0Ulf Gunnarsson1Peter Nygren2Magnus Sundbom3Bengt Glimelius4Haile Mahteme5Department of Surgical Sciences, Uppsala UniversityDepartment of Surgical and Perioperative Sciences, Umeå UniversityDepartment of Immunology, Genetics and Pathology, Uppsala UniversityDepartment of Surgical Sciences, Uppsala UniversityDepartment of Immunology, Genetics and Pathology, Uppsala UniversityDepartment of Surgical Sciences, Uppsala UniversityAbstract Background The aim of this study was to investigate epidemiologic and prognostic factors relevant to the treatment of loco-regionally advanced gastric cancer (GC). Methods Two hundred and fifty-five patients with GC were identified in Uppsala County between 2000 and 2009. Patient records were analyzed for loco-regionally advanced GC defined as tumor with peritoneal involvement, excluding serosal invasion from the primary tumor only, at primary diagnosis or during follow-up. The presence or not of distant metastasis (DM), including hematogenous metastases (e.g., liver, lung, and bone) and/or distant lymph node metastases, was also analyzed. The Cox proportional hazard model was used for multivariate analysis of factors influencing survival. Results One hundred and twenty patients (47% of all patients with GC; median age 70.5 years) had loco-regionally advanced disease, corresponding to an incidence of 3.8 per 100,000 person-years. Forty-one percent of these also had DM. Median overall survival (mOS) from the time of the diagnosis of loco-regionally advanced disease was 4.8 months for the total patient cohort, 5.1 months for the subgroup of patients without DM, and 4.7 months for the subgroup with DM. There was no significant difference in mOS between the subgroups with synchronous versus metachronous loco-regionally advanced GC: 4.8 months (range 0.0–67.4) versus 4.7 months (range 0.0–28.3). Using multivariate Cox analysis, positive prognostic factors for survival were good performance status at diagnosis and treatment with palliative chemotherapy and/or radiotherapy. Synchronous DM was a negative prognostic factor. The mOS did not differ when comparing the time period 2000–2004 (5.1 months, range 0–67.4) with the period 2005–2009 (4.0 months, range 0.0–28.3). Conclusion Peritoneal involvement occurred in almost half of the patients with GC in this study and was associated with short life expectancy. New treatment strategies are warranted.http://link.springer.com/article/10.1186/s12957-017-1243-zSurgeryGastric cancerPeritonealMetastasesPrognostic factorLoco-regionally advanced cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bo Hultman Ulf Gunnarsson Peter Nygren Magnus Sundbom Bengt Glimelius Haile Mahteme |
spellingShingle |
Bo Hultman Ulf Gunnarsson Peter Nygren Magnus Sundbom Bengt Glimelius Haile Mahteme Prognostic factors in patients with loco-regionally advanced gastric cancer World Journal of Surgical Oncology Surgery Gastric cancer Peritoneal Metastases Prognostic factor Loco-regionally advanced cancer |
author_facet |
Bo Hultman Ulf Gunnarsson Peter Nygren Magnus Sundbom Bengt Glimelius Haile Mahteme |
author_sort |
Bo Hultman |
title |
Prognostic factors in patients with loco-regionally advanced gastric cancer |
title_short |
Prognostic factors in patients with loco-regionally advanced gastric cancer |
title_full |
Prognostic factors in patients with loco-regionally advanced gastric cancer |
title_fullStr |
Prognostic factors in patients with loco-regionally advanced gastric cancer |
title_full_unstemmed |
Prognostic factors in patients with loco-regionally advanced gastric cancer |
title_sort |
prognostic factors in patients with loco-regionally advanced gastric cancer |
publisher |
BMC |
series |
World Journal of Surgical Oncology |
issn |
1477-7819 |
publishDate |
2017-09-01 |
description |
Abstract Background The aim of this study was to investigate epidemiologic and prognostic factors relevant to the treatment of loco-regionally advanced gastric cancer (GC). Methods Two hundred and fifty-five patients with GC were identified in Uppsala County between 2000 and 2009. Patient records were analyzed for loco-regionally advanced GC defined as tumor with peritoneal involvement, excluding serosal invasion from the primary tumor only, at primary diagnosis or during follow-up. The presence or not of distant metastasis (DM), including hematogenous metastases (e.g., liver, lung, and bone) and/or distant lymph node metastases, was also analyzed. The Cox proportional hazard model was used for multivariate analysis of factors influencing survival. Results One hundred and twenty patients (47% of all patients with GC; median age 70.5 years) had loco-regionally advanced disease, corresponding to an incidence of 3.8 per 100,000 person-years. Forty-one percent of these also had DM. Median overall survival (mOS) from the time of the diagnosis of loco-regionally advanced disease was 4.8 months for the total patient cohort, 5.1 months for the subgroup of patients without DM, and 4.7 months for the subgroup with DM. There was no significant difference in mOS between the subgroups with synchronous versus metachronous loco-regionally advanced GC: 4.8 months (range 0.0–67.4) versus 4.7 months (range 0.0–28.3). Using multivariate Cox analysis, positive prognostic factors for survival were good performance status at diagnosis and treatment with palliative chemotherapy and/or radiotherapy. Synchronous DM was a negative prognostic factor. The mOS did not differ when comparing the time period 2000–2004 (5.1 months, range 0–67.4) with the period 2005–2009 (4.0 months, range 0.0–28.3). Conclusion Peritoneal involvement occurred in almost half of the patients with GC in this study and was associated with short life expectancy. New treatment strategies are warranted. |
topic |
Surgery Gastric cancer Peritoneal Metastases Prognostic factor Loco-regionally advanced cancer |
url |
http://link.springer.com/article/10.1186/s12957-017-1243-z |
work_keys_str_mv |
AT bohultman prognosticfactorsinpatientswithlocoregionallyadvancedgastriccancer AT ulfgunnarsson prognosticfactorsinpatientswithlocoregionallyadvancedgastriccancer AT peternygren prognosticfactorsinpatientswithlocoregionallyadvancedgastriccancer AT magnussundbom prognosticfactorsinpatientswithlocoregionallyadvancedgastriccancer AT bengtglimelius prognosticfactorsinpatientswithlocoregionallyadvancedgastriccancer AT hailemahteme prognosticfactorsinpatientswithlocoregionallyadvancedgastriccancer |
_version_ |
1716752015086845952 |