The Balance in T Follicular Helper Cell Subsets Is Altered in Neuromyelitis Optica Spectrum Disorder Patients and Restored by Rituximab

The Balance in T Follicular Helper Cell Subsets Is Altered in Neuromyelitis Optica Spectrum Disorder Patients and Restored by Rituximab

Neuromyelitis optica spectrum disorder (NMOSD) is a rare and severe auto-immune disease of the central nervous system driven by pathogenic antibodies mainly directed against aquaporin-4 (AQP4-Ab). Treatment of NMOSD currently relies on immunosuppressants (mycophenolate mofetil, azathioprine) or B-ce...

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Bibliographic Details
Main Authors: Philippe Nicolas, Anne Ruiz, Alvaro Cobo-Calvo, Guillaume Fiard, Pascale Giraudon, Sandra Vukusic, Romain Marignier
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
neuromyelitis optica spectrum disorder
T follicular helper cells
T follicular regulatory cells
B cells
rituximab
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02686/full

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