Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Aquaporins in the Brain

Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Aquaporins in the Brain

Water homeostasis of the brain is essential for its neuronal activity. Changes in water content in the intra- and extra-cellular space affect ionic concentrations and therefore modify neuronal activity. Aquaporin (AQP) water channels may have a central role in keeping water homeostasis in the brain....

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Main Authors: Hideyuki Kobayashi, Toshihiko Yanagita, Hiroki Yokoo, Akihiko Wada
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319323370
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spelling doaj-9214b5d7a5344ce8afb932080982bee32020-11-25T01:20:32ZengElsevierJournal of Pharmacological Sciences1347-86132004-01-01963264270Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Aquaporins in the BrainHideyuki Kobayashi0Toshihiko Yanagita1Hiroki Yokoo2Akihiko Wada3Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan; Corresponding author. FAX: +81-985-84-2776 E-mail: hkobayas@med.miyazaki-u.ac.jpDepartment of Pharmacology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Pharmacology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanDepartment of Pharmacology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, JapanWater homeostasis of the brain is essential for its neuronal activity. Changes in water content in the intra- and extra-cellular space affect ionic concentrations and therefore modify neuronal activity. Aquaporin (AQP) water channels may have a central role in keeping water homeostasis in the brain. Among AQP subtypes cloned in mammalian, only AQP1, AQP4, and AQP9 were identified in the brain. Changes in AQP expression may be correlated with edema formation of the brain. In this review, we describe the physiological function of AQPs and the regulatory mechanism of their expression in the brain. Keywords:: aquaporin, brain, edema, glucocorticoid, lipid rafthttp://www.sciencedirect.com/science/article/pii/S1347861319323370
collection DOAJ
language English
format Article
sources DOAJ
author Hideyuki Kobayashi
Toshihiko Yanagita
Hiroki Yokoo
Akihiko Wada
spellingShingle Hideyuki Kobayashi
Toshihiko Yanagita
Hiroki Yokoo
Akihiko Wada
Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Aquaporins in the Brain
Journal of Pharmacological Sciences
author_facet Hideyuki Kobayashi
Toshihiko Yanagita
Hiroki Yokoo
Akihiko Wada
author_sort Hideyuki Kobayashi
title Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Aquaporins in the Brain
title_short Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Aquaporins in the Brain
title_full Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Aquaporins in the Brain
title_fullStr Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Aquaporins in the Brain
title_full_unstemmed Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Aquaporins in the Brain
title_sort molecular mechanisms and drug development in aquaporin water channel diseases: aquaporins in the brain
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2004-01-01
description Water homeostasis of the brain is essential for its neuronal activity. Changes in water content in the intra- and extra-cellular space affect ionic concentrations and therefore modify neuronal activity. Aquaporin (AQP) water channels may have a central role in keeping water homeostasis in the brain. Among AQP subtypes cloned in mammalian, only AQP1, AQP4, and AQP9 were identified in the brain. Changes in AQP expression may be correlated with edema formation of the brain. In this review, we describe the physiological function of AQPs and the regulatory mechanism of their expression in the brain. Keywords:: aquaporin, brain, edema, glucocorticoid, lipid raft
url http://www.sciencedirect.com/science/article/pii/S1347861319323370
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AT hirokiyokoo molecularmechanismsanddrugdevelopmentinaquaporinwaterchanneldiseasesaquaporinsinthebrain
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