Progranulin depletion inhibits proliferation via the transforming growth factor beta/SMAD family member 2 signaling axis in Kasumi-1 cells

Progranulin depletion inhibits proliferation via the transforming growth factor beta/SMAD family member 2 signaling axis in Kasumi-1 cells

Progranulin is an autocrine growth factor that promotes proliferation, migration, invasion, and chemoresistance of various cancer cells. These mechanisms mainly depend on the protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway. Recent studies have shown that patients with hematopoi...

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Bibliographic Details
Main Authors: Kuniaki Yabe, Yasuko Yamamoto, Masao Takemura, Takeshi Hara, Hisashi Tsurumi, Ginette Serrero, Toshitaka Nabeshima, Kuniaki Saito
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Heliyon
Subjects:
Hematologic neoplasms
Progranulin
Mechanistic target of rapamycin complex 1
Transforming growth factor beta
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020326918

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http://www.sciencedirect.com/science/article/pii/S2405844020326918

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