S100A4 Protects Myeloid-Derived Suppressor Cells from Intrinsic Apoptosis via TLR4–ERK1/2 Signaling

S100A4 Protects Myeloid-Derived Suppressor Cells from Intrinsic Apoptosis via TLR4–ERK1/2 Signaling

Myeloid-derived suppressor cells (MDSCs) often expand during cancer or chronic inflammation and dampen immune responses. However, mechanisms underlying their capacity to escape intrinsic apoptosis in the inflammatory environment are still largely unknown. In this study, we investigated this in mouse...

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Bibliographic Details
Main Authors: Qingcui Li, Chengliang Dai, Rui Xue, Peigang Wang, Lin Chen, Yijie Han, Ulrike Erben, Zhihai Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
S100A4
myeloid-derived suppressor cells
intrinsic apoptosis
toll-like receptor-4
ERK1/2 signaling
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00388/full

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