Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study
Advanced head and neck (H&N) tumors have a poor prognosis, and this is worsened by the occurrence of hypoxia and ischemia in the tumors. Ozonetherapy has proved useful in the treatment of ischemic syndromes, and several studies have described a potential increase of oxygenation in tissues and tu...
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doaj-92287913018443c9bac69db53d6b65912020-11-24T20:59:58ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882004-01-011332132510.1093/ecam/neh038Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative StudyBernardino Clavo0Ana Ruiz1Marta Lloret2Laura López3Gerardo Suárez4David Macías5Victor Rodríguez6Maria A. Hernández7Roberto Martín-Oliva8Santiago Quintero9José M. Cuyás10Francisco Robaina11Department of Radiation Oncology-Research Unit, Las Palmas, Canary Islands, SpainDepartment of Radiation Oncology-Research Unit, Las Palmas, Canary Islands, SpainDepartment of Radiation Oncology-Research Unit, Las Palmas, Canary Islands, SpainDepartment of Radiation Oncology-Research Unit, Las Palmas, Canary Islands, SpainDepartment of Radiation Oncology-Research Unit, Las Palmas, Canary Islands, SpainDepartment of Medical Physics, Las Palmas, Canary Islands, SpainLa Paterna Medical Center Las Palmas, Canary Islands, SpainDepartment of Radiation Oncology-Research Unit, Las Palmas, Canary Islands, SpainDepartment of Medical Physics, Las Palmas, Canary Islands, SpainDepartment of Oral and Maxillofacial Surgery, Las Palmas, Canary Islands, SpainDepartment of Otolaryngology, Las Palmas, Canary Islands, SpainDepartment of Neurosurgery and Chronic Pain Unit of the Dr Negrín Hospital, Las Palmas, Canary Islands, SpainAdvanced head and neck (H&N) tumors have a poor prognosis, and this is worsened by the occurrence of hypoxia and ischemia in the tumors. Ozonetherapy has proved useful in the treatment of ischemic syndromes, and several studies have described a potential increase of oxygenation in tissues and tumors. The aim of this prospective study was to evaluate the clinical effect of ozonetherapy in patients with advanced H&N cancer in the course of their scheduled radiotherapy. Over a period of 3 years, 19 patients with advanced H&N tumors who were undergoing treatment in our department with non-standard fractionated radiotherapy plus oral tegafur. A group of 12 patients was additionally treated with intravenous chemotherapy before and/or during radiotherapy. In the other group of seven patients, systemic ozonetherapy was administered twice weekly during radiotherapy. The ozonetherapy group was older (64 versus 54 years old, P = 0.006), with a higher percentage of lymph node involvement (71% versus 8%, P = 0.019) and with a trend to more unfavorable tumor stage (57% versus 8% IVb + IVc stages, P = 0.073). However, there was no significant difference in overall survival between the chemotherapy (median 6 months) and ozonetherapy (8 months) groups. Although these results have to be viewed with caution because of the limited number of patients, they suggest that ozonetherapy could have had some positive effect during the treatment of our patients with advanced H&N tumors. The adjuvant administration of ozonetherapy during the chemo–radiotherapy for these tumors merits further research.http://dx.doi.org/10.1093/ecam/neh038 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bernardino Clavo Ana Ruiz Marta Lloret Laura López Gerardo Suárez David Macías Victor Rodríguez Maria A. Hernández Roberto Martín-Oliva Santiago Quintero José M. Cuyás Francisco Robaina |
spellingShingle |
Bernardino Clavo Ana Ruiz Marta Lloret Laura López Gerardo Suárez David Macías Victor Rodríguez Maria A. Hernández Roberto Martín-Oliva Santiago Quintero José M. Cuyás Francisco Robaina Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study Evidence-Based Complementary and Alternative Medicine |
author_facet |
Bernardino Clavo Ana Ruiz Marta Lloret Laura López Gerardo Suárez David Macías Victor Rodríguez Maria A. Hernández Roberto Martín-Oliva Santiago Quintero José M. Cuyás Francisco Robaina |
author_sort |
Bernardino Clavo |
title |
Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study |
title_short |
Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study |
title_full |
Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study |
title_fullStr |
Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study |
title_full_unstemmed |
Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study |
title_sort |
adjuvant ozonetherapy in advanced head and neck tumors: a comparative study |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2004-01-01 |
description |
Advanced head and neck (H&N) tumors have a poor prognosis, and this is worsened by the occurrence of hypoxia and ischemia in the tumors. Ozonetherapy has proved useful in the treatment of ischemic syndromes, and several studies have described a potential increase of oxygenation in tissues and tumors. The aim of this prospective study was to evaluate the clinical effect of ozonetherapy in patients with advanced H&N cancer in the course of their scheduled radiotherapy. Over a period of 3 years, 19 patients with advanced H&N tumors who were undergoing treatment in our department with non-standard fractionated radiotherapy plus oral tegafur. A group of 12 patients was additionally treated with intravenous chemotherapy before and/or during radiotherapy. In the other group of seven patients, systemic ozonetherapy was administered twice weekly during radiotherapy. The ozonetherapy group was older (64 versus 54 years old, P = 0.006), with a higher percentage of lymph node involvement (71% versus 8%, P = 0.019) and with a trend to more unfavorable tumor stage (57% versus 8% IVb + IVc stages, P = 0.073). However, there was no significant difference in overall survival between the chemotherapy (median 6 months) and ozonetherapy (8 months) groups. Although these results have to be viewed with caution because of the limited number of patients, they suggest that ozonetherapy could have had some positive effect during the treatment of our patients with advanced H&N tumors. The adjuvant administration of ozonetherapy during the chemo–radiotherapy for these tumors merits further research. |
url |
http://dx.doi.org/10.1093/ecam/neh038 |
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