Transbronchial lung biopsy in patients with diffuse parenchymal lung disease without 'idiopathic pulmonary fibrosis pattern' on HRCT scan - Experience from a tertiary care center of North India
Background: Diffuse parenchymal lung diseases (DPLD) are a group of disorders characterized by chest radiological findings of bilateral diffuse shadowing. Lung biopsy is generally required to make an etiological diagnosis of DPLD's. Transbronchial lung biopsy (TBLB) is a minimally invasive meth...
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doaj-92308795928d46d39740a62610d1df0a2020-11-24T20:54:25ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2015-01-0132545345610.4103/0970-2113.164148Transbronchial lung biopsy in patients with diffuse parenchymal lung disease without 'idiopathic pulmonary fibrosis pattern' on HRCT scan - Experience from a tertiary care center of North IndiaGirish SindhwaniNadia ShiraziRakhee SodhiShailendra RaghuvanshiJagdish RawatBackground: Diffuse parenchymal lung diseases (DPLD) are a group of disorders characterized by chest radiological findings of bilateral diffuse shadowing. Lung biopsy is generally required to make an etiological diagnosis of DPLD's. Transbronchial lung biopsy (TBLB) is a minimally invasive method to achieve a lung sample which has been found to be a useful diagnostic tool in patients with DPLD. As per American Thoracic Society guidelines for management of idiopathic interstitial pneumonias, TBLB is not required in patients who have findings consistent with idiopathic pulmonary fibrosis (IPF) on HRCT scan thorax. Some Indian researchers have evaluated, on a small number of subjects, the role of TBLB in patients with DPLD, but they had not excluded patients with 'IPF pattern'. This study was planned to assess TBLB in patients with DPLD after excluding patients with 'IPF pattern'. Materials and Methods: A prospective non-randomized study on 49 patients with DPLD without a characteristic 'IPF pattern' were subjected to TBLB. Results: The overall diagnostic yield of TBLB was 85.7%. Non-specific interstitial pneumonitis, tuberculosis and sarcoidosis were the most common histology patterns found (22.4, 18.4 and 16.3%, respectively). Procedure-related mortality was nil. Iatrogenic pneumothorax occurred in five patients (10.2%). Minor complications included hemorrhage and transient hypoxia. Conclusion: TBLB is a safe and effective tool in the diagnosis of DPLD.http://www.lungindia.com/article.asp?issn=0970-2113;year=2015;volume=32;issue=5;spage=453;epage=456;aulast=SindhwaniDiffuse parenchymal lung diseaseidiopathic pulmonary fibrosistransbronchial lung biopsy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Girish Sindhwani Nadia Shirazi Rakhee Sodhi Shailendra Raghuvanshi Jagdish Rawat |
spellingShingle |
Girish Sindhwani Nadia Shirazi Rakhee Sodhi Shailendra Raghuvanshi Jagdish Rawat Transbronchial lung biopsy in patients with diffuse parenchymal lung disease without 'idiopathic pulmonary fibrosis pattern' on HRCT scan - Experience from a tertiary care center of North India Lung India Diffuse parenchymal lung disease idiopathic pulmonary fibrosis transbronchial lung biopsy |
author_facet |
Girish Sindhwani Nadia Shirazi Rakhee Sodhi Shailendra Raghuvanshi Jagdish Rawat |
author_sort |
Girish Sindhwani |
title |
Transbronchial lung biopsy in patients with diffuse parenchymal lung disease without 'idiopathic pulmonary fibrosis pattern' on HRCT scan - Experience from a tertiary care center of North India |
title_short |
Transbronchial lung biopsy in patients with diffuse parenchymal lung disease without 'idiopathic pulmonary fibrosis pattern' on HRCT scan - Experience from a tertiary care center of North India |
title_full |
Transbronchial lung biopsy in patients with diffuse parenchymal lung disease without 'idiopathic pulmonary fibrosis pattern' on HRCT scan - Experience from a tertiary care center of North India |
title_fullStr |
Transbronchial lung biopsy in patients with diffuse parenchymal lung disease without 'idiopathic pulmonary fibrosis pattern' on HRCT scan - Experience from a tertiary care center of North India |
title_full_unstemmed |
Transbronchial lung biopsy in patients with diffuse parenchymal lung disease without 'idiopathic pulmonary fibrosis pattern' on HRCT scan - Experience from a tertiary care center of North India |
title_sort |
transbronchial lung biopsy in patients with diffuse parenchymal lung disease without 'idiopathic pulmonary fibrosis pattern' on hrct scan - experience from a tertiary care center of north india |
publisher |
Wolters Kluwer Medknow Publications |
series |
Lung India |
issn |
0970-2113 0974-598X |
publishDate |
2015-01-01 |
description |
Background: Diffuse parenchymal lung diseases (DPLD) are a group of disorders characterized by chest radiological findings of bilateral diffuse shadowing. Lung biopsy is generally required to make an etiological diagnosis of DPLD's. Transbronchial lung biopsy (TBLB) is a minimally invasive method to achieve a lung sample which has been found to be a useful diagnostic tool in patients with DPLD. As per American Thoracic Society guidelines for management of idiopathic interstitial pneumonias, TBLB is not required in patients who have findings consistent with idiopathic pulmonary fibrosis (IPF) on HRCT scan thorax. Some Indian researchers have evaluated, on a small number of subjects, the role of TBLB in patients with DPLD, but they had not excluded patients with 'IPF pattern'. This study was planned to assess TBLB in patients with DPLD after excluding patients with 'IPF pattern'. Materials and Methods: A prospective non-randomized study on 49 patients with DPLD without a characteristic 'IPF pattern' were subjected to TBLB. Results: The overall diagnostic yield of TBLB was 85.7%. Non-specific interstitial pneumonitis, tuberculosis and sarcoidosis were the most common histology patterns found (22.4, 18.4 and 16.3%, respectively). Procedure-related mortality was nil. Iatrogenic pneumothorax occurred in five patients (10.2%). Minor complications included hemorrhage and transient hypoxia. Conclusion: TBLB is a safe and effective tool in the diagnosis of DPLD. |
topic |
Diffuse parenchymal lung disease idiopathic pulmonary fibrosis transbronchial lung biopsy |
url |
http://www.lungindia.com/article.asp?issn=0970-2113;year=2015;volume=32;issue=5;spage=453;epage=456;aulast=Sindhwani |
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