HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer

HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer

Abstract Background Tumour hypoxia is a driver of breast cancer progression associated with worse prognosis and more aggressive disease. The cellular response to hypoxia is mediated by the hypoxia-inducible transcription factors HIF-1 and HIF-2, whose transcriptional activity is canonically regulate...

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Bibliographic Details
Main Authors: Edward J. Jarman, Carol Ward, Arran K. Turnbull, Carlos Martinez-Perez, James Meehan, Chrysi Xintaropoulou, Andrew H. Sims, Simon P. Langdon
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Breast Cancer Research
Subjects:
Hypoxia-inducible factors
HIF-2α
HER2
Hypoxia
Online Access:http://link.springer.com/article/10.1186/s13058-019-1097-0

Internet

http://link.springer.com/article/10.1186/s13058-019-1097-0

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