Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable t...
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Frontiers Media S.A.
2021-02-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.609961/full |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
E. Eduardo Sanchez-Castro Cecilia Pajuelo-Reyes Rebeca Tejedo Bárbara Soria-Juan Bárbara Soria-Juan Rafael Tapia-Limonchi Etelvina Andreu Etelvina Andreu Ana B. Hitos Ana B. Hitos Franz Martin Franz Martin Franz Martin Gladys M. Cahuana Gladys M. Cahuana Clara Guerra-Duarte Thamyres C. Silva de Assis Francisco J. Bedoya Francisco J. Bedoya Francisco J. Bedoya Bernat Soria Bernat Soria Bernat Soria Bernat Soria Carlos Chávez-Olórtegui Juan R. Tejedo Juan R. Tejedo Juan R. Tejedo Juan R. Tejedo |
spellingShingle |
E. Eduardo Sanchez-Castro Cecilia Pajuelo-Reyes Rebeca Tejedo Bárbara Soria-Juan Bárbara Soria-Juan Rafael Tapia-Limonchi Etelvina Andreu Etelvina Andreu Ana B. Hitos Ana B. Hitos Franz Martin Franz Martin Franz Martin Gladys M. Cahuana Gladys M. Cahuana Clara Guerra-Duarte Thamyres C. Silva de Assis Francisco J. Bedoya Francisco J. Bedoya Francisco J. Bedoya Bernat Soria Bernat Soria Bernat Soria Bernat Soria Carlos Chávez-Olórtegui Juan R. Tejedo Juan R. Tejedo Juan R. Tejedo Juan R. Tejedo Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming Frontiers in Immunology advanced therapy medicinal products mesenchymal stromal cells snakebite envenoming muscle regeneration |
author_facet |
E. Eduardo Sanchez-Castro Cecilia Pajuelo-Reyes Rebeca Tejedo Bárbara Soria-Juan Bárbara Soria-Juan Rafael Tapia-Limonchi Etelvina Andreu Etelvina Andreu Ana B. Hitos Ana B. Hitos Franz Martin Franz Martin Franz Martin Gladys M. Cahuana Gladys M. Cahuana Clara Guerra-Duarte Thamyres C. Silva de Assis Francisco J. Bedoya Francisco J. Bedoya Francisco J. Bedoya Bernat Soria Bernat Soria Bernat Soria Bernat Soria Carlos Chávez-Olórtegui Juan R. Tejedo Juan R. Tejedo Juan R. Tejedo Juan R. Tejedo |
author_sort |
E. Eduardo Sanchez-Castro |
title |
Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming |
title_short |
Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming |
title_full |
Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming |
title_fullStr |
Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming |
title_full_unstemmed |
Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming |
title_sort |
mesenchymal stromal cell-based therapies as promising treatments for muscle regeneration after snakebite envenoming |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-02-01 |
description |
Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects. Local damage, such as dermonecrosis and myonecrosis, can lead to permanent sequelae with physical, social, and psychological implications. The strong inflammatory process induced by snake venoms is associated with poor tissue regeneration, in particular the lack of or reduced skeletal muscle regeneration. Mesenchymal stromal cells (MSCs)-based therapies have shown both anti-inflammatory and pro-regenerative properties. We postulate that using allogeneic MSCs or their cell-free products can induce skeletal muscle regeneration in snakebite victims, improving all the three steps of the skeletal muscle regeneration process, mainly by anti-inflammatory activity, paracrine effects, neovascularization induction, and inhibition of tissue damage, instrumental for microenvironment remodeling and regeneration. Since snakebite envenoming occurs mainly in areas with poor healthcare, we enlist the principles and potential of MSCs-based therapies and discuss regulatory issues, good manufacturing practices, transportation, storage, and related-procedures that could allow the administration of these therapies, looking forward to a safe and cost-effective treatment for a so far unsolved and neglected health problem. |
topic |
advanced therapy medicinal products mesenchymal stromal cells snakebite envenoming muscle regeneration |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2020.609961/full |
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doaj-9243028502be455d8b55b0e2fc24f46c2021-02-03T05:20:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011110.3389/fimmu.2020.609961609961Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite EnvenomingE. Eduardo Sanchez-Castro0Cecilia Pajuelo-Reyes1Rebeca Tejedo2Bárbara Soria-Juan3Bárbara Soria-Juan4Rafael Tapia-Limonchi5Etelvina Andreu6Etelvina Andreu7Ana B. Hitos8Ana B. Hitos9Franz Martin10Franz Martin11Franz Martin12Gladys M. Cahuana13Gladys M. Cahuana14Clara Guerra-Duarte15Thamyres C. Silva de Assis16Francisco J. Bedoya17Francisco J. Bedoya18Francisco J. Bedoya19Bernat Soria20Bernat Soria21Bernat Soria22Bernat Soria23Carlos Chávez-Olórtegui24Juan R. Tejedo25Juan R. Tejedo26Juan R. Tejedo27Juan R. Tejedo28Faculty of Biological Sciences, Universidad Nacional Mayor de San Marcos, Lima, PeruInstitute of Tropical Diseases, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, PeruFaculty of Medicine, Universidad Privada San Juan Bautista, Lima, PeruDepartment of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, SpainDepartment of Surgery, Fundación Jiménez Díaz, Unidad de Terapias Avanzadas, Universidad Autónoma de Madrid, Madrid, SpainInstitute of Tropical Diseases, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, PeruISABIAL-Hospital General y Universitario de Alicante, Alicante, SpainDepartmento de Fisica Aplicadas, University Miguel Hernández, Alicante, SpainDepartment of Cell Regeneration and Advanced Therapies, Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, University of Pablo de Olavide-University of Sevilla-CSIC, Seville, SpainBiomedical Research Network for Diabetes and Related Metabolic Diseases—CIBERDEM, Instituto de Salud Carlos III, Madrid, SpainDepartment of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, SpainDepartment of Cell Regeneration and Advanced Therapies, Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, University of Pablo de Olavide-University of Sevilla-CSIC, Seville, SpainBiomedical Research Network for Diabetes and Related Metabolic Diseases—CIBERDEM, Instituto de Salud Carlos III, Madrid, SpainDepartment of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, SpainDepartment of Cell Regeneration and Advanced Therapies, Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, University of Pablo de Olavide-University of Sevilla-CSIC, Seville, Spain0Center of Research and Development, Fundação Ezequiel Dias, Belo Horizonte, Brazil1Departament of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilDepartment of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, SpainDepartment of Cell Regeneration and Advanced Therapies, Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, University of Pablo de Olavide-University of Sevilla-CSIC, Seville, SpainBiomedical Research Network for Diabetes and Related Metabolic Diseases—CIBERDEM, Instituto de Salud Carlos III, Madrid, SpainDepartment of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, SpainISABIAL-Hospital General y Universitario de Alicante, Alicante, SpainBiomedical Research Network for Diabetes and Related Metabolic Diseases—CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain2Institute of Bioengineering, University Miguel Hernandez de Elche, Alicante, Spain1Departament of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, BrazilInstitute of Tropical Diseases, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, PeruDepartment of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, SpainDepartment of Cell Regeneration and Advanced Therapies, Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, University of Pablo de Olavide-University of Sevilla-CSIC, Seville, SpainBiomedical Research Network for Diabetes and Related Metabolic Diseases—CIBERDEM, Instituto de Salud Carlos III, Madrid, SpainSnakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects. Local damage, such as dermonecrosis and myonecrosis, can lead to permanent sequelae with physical, social, and psychological implications. The strong inflammatory process induced by snake venoms is associated with poor tissue regeneration, in particular the lack of or reduced skeletal muscle regeneration. Mesenchymal stromal cells (MSCs)-based therapies have shown both anti-inflammatory and pro-regenerative properties. We postulate that using allogeneic MSCs or their cell-free products can induce skeletal muscle regeneration in snakebite victims, improving all the three steps of the skeletal muscle regeneration process, mainly by anti-inflammatory activity, paracrine effects, neovascularization induction, and inhibition of tissue damage, instrumental for microenvironment remodeling and regeneration. Since snakebite envenoming occurs mainly in areas with poor healthcare, we enlist the principles and potential of MSCs-based therapies and discuss regulatory issues, good manufacturing practices, transportation, storage, and related-procedures that could allow the administration of these therapies, looking forward to a safe and cost-effective treatment for a so far unsolved and neglected health problem.https://www.frontiersin.org/articles/10.3389/fimmu.2020.609961/fulladvanced therapy medicinal productsmesenchymal stromal cellssnakebiteenvenomingmuscle regeneration |