Role of low dose cytarabine in elderly patients with acute myeloid leukemia: An experience
Purpose: To highlight the acceptable results seen after use of low dose cytarabine in elderly patients of acute myeloid leukemia (AML) with comorbidities. Materials and Methods: This was a prospective study carried on 30 newly diagnosed patients of AML over 60 years of age who were unfit for standar...
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2015-01-01
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doaj-9249fe3fa9d74ca4906d2de5287484c02020-12-02T17:59:01ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062015-01-01414610.4103/2278-330X.149918Role of low dose cytarabine in elderly patients with acute myeloid leukemia: An experienceYasir BashirSajjad GeelaniNusrat BashirShabeer A MirMosin MushtaqM Aleem JanJavid RasoolPurpose: To highlight the acceptable results seen after use of low dose cytarabine in elderly patients of acute myeloid leukemia (AML) with comorbidities. Materials and Methods: This was a prospective study carried on 30 newly diagnosed patients of AML over 60 years of age who were unfit for standard treatment regimens. We did not use azacytidine and decitabine in our patients because these therapeutic modalities being extremely costly and our patient affordability being poor. After taking patient consent and institutional ethical clearance these patients were treated with 20 mg/m 2 cytarabine subcutaneously in two divided doses 12 h apart for 4 days every week for 4 weeks which constituted a cycle before disease, re-assessment was done. A repeat cycle was administered where ever needed and after attainment of remission, we continued low dose cytarabine for 2 days/week as maintenance after complete or partial response was documented. Results: In our study, we found that around 20% of patients achieved complete remission and 30% partial remission. The remission rates were definitely influenced by counts at presentation, performance at presentation, comorbidities, underlying myelodysplastic syndrome and baseline cytogenetics. Conclusion: Low dose cytarabine is effective treatment option for elderly patients with AML when standard treatment options are not warranted.http://journal.sajc.org/article.asp?issn=2278-330X;year=2015;volume=4;issue=1;spage=4;epage=6;aulast=BashirComorbidityelderly acute myeloid leukemialow dose cytarabine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yasir Bashir Sajjad Geelani Nusrat Bashir Shabeer A Mir Mosin Mushtaq M Aleem Jan Javid Rasool |
spellingShingle |
Yasir Bashir Sajjad Geelani Nusrat Bashir Shabeer A Mir Mosin Mushtaq M Aleem Jan Javid Rasool Role of low dose cytarabine in elderly patients with acute myeloid leukemia: An experience South Asian Journal of Cancer Comorbidity elderly acute myeloid leukemia low dose cytarabine |
author_facet |
Yasir Bashir Sajjad Geelani Nusrat Bashir Shabeer A Mir Mosin Mushtaq M Aleem Jan Javid Rasool |
author_sort |
Yasir Bashir |
title |
Role of low dose cytarabine in elderly patients with acute myeloid leukemia: An experience |
title_short |
Role of low dose cytarabine in elderly patients with acute myeloid leukemia: An experience |
title_full |
Role of low dose cytarabine in elderly patients with acute myeloid leukemia: An experience |
title_fullStr |
Role of low dose cytarabine in elderly patients with acute myeloid leukemia: An experience |
title_full_unstemmed |
Role of low dose cytarabine in elderly patients with acute myeloid leukemia: An experience |
title_sort |
role of low dose cytarabine in elderly patients with acute myeloid leukemia: an experience |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
South Asian Journal of Cancer |
issn |
2278-330X 2278-4306 |
publishDate |
2015-01-01 |
description |
Purpose: To highlight the acceptable results seen after use of low dose cytarabine in elderly patients of acute myeloid leukemia (AML) with comorbidities. Materials and Methods: This was a prospective study carried on 30 newly diagnosed patients of AML over 60 years of age who were unfit for standard treatment regimens. We did not use azacytidine and decitabine in our patients because these therapeutic modalities being extremely costly and our patient affordability being poor. After taking patient consent and institutional ethical clearance these patients were treated with 20 mg/m 2 cytarabine subcutaneously in two divided doses 12 h apart for 4 days every week for 4 weeks which constituted a cycle before disease, re-assessment was done. A repeat cycle was administered where ever needed and after attainment of remission, we continued low dose cytarabine for 2 days/week as maintenance after complete or partial response was documented. Results: In our study, we found that around 20% of patients achieved complete remission and 30% partial remission. The remission rates were definitely influenced by counts at presentation, performance at presentation, comorbidities, underlying myelodysplastic syndrome and baseline cytogenetics. Conclusion: Low dose cytarabine is effective treatment option for elderly patients with AML when standard treatment options are not warranted. |
topic |
Comorbidity elderly acute myeloid leukemia low dose cytarabine |
url |
http://journal.sajc.org/article.asp?issn=2278-330X;year=2015;volume=4;issue=1;spage=4;epage=6;aulast=Bashir |
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