Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms

Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms

The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have d...

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Main Authors: Ning Yi Yap, Retnagowri Rajandram, Keng Lim Ng, Jayalakshmi Pailoor, Ahmad Fadzli, Glenda Carolyn Gobe
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/476508
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spelling doaj-924b0029a0db4de6b9b4be53cd2667a12020-11-24T20:59:50ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/476508476508Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal NeoplasmsNing Yi Yap0Retnagowri Rajandram1Keng Lim Ng2Jayalakshmi Pailoor3Ahmad Fadzli4Glenda Carolyn Gobe5Department of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, MalaysiaDepartment of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, MalaysiaDepartment of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, MalaysiaDepartment of Pathology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, MalaysiaDepartment of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, MalaysiaCentre for Kidney Disease Research, University of Queensland, Translational Research Institute, 37 Kent Street, Brisbane QLD 4102, AustraliaThe most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes. Genomic and molecular studies have revealed unique genetic aberrations in each subtype. Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression. In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways. The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed.http://dx.doi.org/10.1155/2015/476508
collection DOAJ
language English
format Article
sources DOAJ
author Ning Yi Yap
Retnagowri Rajandram
Keng Lim Ng
Jayalakshmi Pailoor
Ahmad Fadzli
Glenda Carolyn Gobe
spellingShingle Ning Yi Yap
Retnagowri Rajandram
Keng Lim Ng
Jayalakshmi Pailoor
Ahmad Fadzli
Glenda Carolyn Gobe
Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
BioMed Research International
author_facet Ning Yi Yap
Retnagowri Rajandram
Keng Lim Ng
Jayalakshmi Pailoor
Ahmad Fadzli
Glenda Carolyn Gobe
author_sort Ning Yi Yap
title Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
title_short Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
title_full Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
title_fullStr Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
title_full_unstemmed Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
title_sort genetic and chromosomal aberrations and their clinical significance in renal neoplasms
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2015-01-01
description The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes. Genomic and molecular studies have revealed unique genetic aberrations in each subtype. Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression. In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways. The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed.
url http://dx.doi.org/10.1155/2015/476508
work_keys_str_mv AT ningyiyap geneticandchromosomalaberrationsandtheirclinicalsignificanceinrenalneoplasms
AT retnagowrirajandram geneticandchromosomalaberrationsandtheirclinicalsignificanceinrenalneoplasms
AT kenglimng geneticandchromosomalaberrationsandtheirclinicalsignificanceinrenalneoplasms
AT jayalakshmipailoor geneticandchromosomalaberrationsandtheirclinicalsignificanceinrenalneoplasms
AT ahmadfadzli geneticandchromosomalaberrationsandtheirclinicalsignificanceinrenalneoplasms
AT glendacarolyngobe geneticandchromosomalaberrationsandtheirclinicalsignificanceinrenalneoplasms
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