Host and Microbiome Genome-Wide Association Studies: Current State and Challenges

The involvement of the microbiome in health and disease is well established. Microbiome genome-wide association studies (mGWAS) are used to elucidate the interaction of host genetic variation with the microbiome. The emergence of this relatively new field has been facilitated by the advent of next g...

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Main Authors:	Denis Awany, Imane Allali, Shareefa Dalvie, Sian Hemmings, Kilaza S. Mwaikono, Nicholas E. Thomford, Andres Gomez, Nicola Mulder, Emile R. Chimusa
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-01-01
Series:	Frontiers in Genetics
Subjects:	genome-wide association study microbiome microbiome-GWAS host-genetic host–microbiome interaction
Online Access:	https://www.frontiersin.org/article/10.3389/fgene.2018.00637/full

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spelling	doaj-9261a0a15dde4b9a8596eae1feb555902020-11-24T22:24:07ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-01-01910.3389/fgene.2018.00637420890Host and Microbiome Genome-Wide Association Studies: Current State and ChallengesDenis Awany0Imane Allali1Shareefa Dalvie2Sian Hemmings3Kilaza S. Mwaikono4Nicholas E. Thomford5Andres Gomez6Nicola Mulder7Emile R. Chimusa8Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaComputational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South AfricaDepartment of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South AfricaComputational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaDivision of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaDepartment of Animal Science, University of Minnesota-Twin Cities, St. Paul, MN, United StatesComputational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaDivision of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South AfricaThe involvement of the microbiome in health and disease is well established. Microbiome genome-wide association studies (mGWAS) are used to elucidate the interaction of host genetic variation with the microbiome. The emergence of this relatively new field has been facilitated by the advent of next generation sequencing technologies that enable the investigation of the complex interaction between host genetics and microbial communities. In this paper, we review recent studies investigating host–microbiome interactions using mGWAS. Additionally, we highlight the marked disparity in the sampling population of mGWAS carried out to date and draw attention to the critical need for inclusion of diverse populations.https://www.frontiersin.org/article/10.3389/fgene.2018.00637/fullgenome-wide association studymicrobiomemicrobiome-GWAShost-genetichost–microbiome interaction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Denis Awany Imane Allali Shareefa Dalvie Sian Hemmings Kilaza S. Mwaikono Nicholas E. Thomford Andres Gomez Nicola Mulder Emile R. Chimusa
spellingShingle	Denis Awany Imane Allali Shareefa Dalvie Sian Hemmings Kilaza S. Mwaikono Nicholas E. Thomford Andres Gomez Nicola Mulder Emile R. Chimusa Host and Microbiome Genome-Wide Association Studies: Current State and Challenges Frontiers in Genetics genome-wide association study microbiome microbiome-GWAS host-genetic host–microbiome interaction
author_facet	Denis Awany Imane Allali Shareefa Dalvie Sian Hemmings Kilaza S. Mwaikono Nicholas E. Thomford Andres Gomez Nicola Mulder Emile R. Chimusa
author_sort	Denis Awany
title	Host and Microbiome Genome-Wide Association Studies: Current State and Challenges
title_short	Host and Microbiome Genome-Wide Association Studies: Current State and Challenges
title_full	Host and Microbiome Genome-Wide Association Studies: Current State and Challenges
title_fullStr	Host and Microbiome Genome-Wide Association Studies: Current State and Challenges
title_full_unstemmed	Host and Microbiome Genome-Wide Association Studies: Current State and Challenges
title_sort	host and microbiome genome-wide association studies: current state and challenges
publisher	Frontiers Media S.A.
series	Frontiers in Genetics
issn	1664-8021
publishDate	2019-01-01
description	The involvement of the microbiome in health and disease is well established. Microbiome genome-wide association studies (mGWAS) are used to elucidate the interaction of host genetic variation with the microbiome. The emergence of this relatively new field has been facilitated by the advent of next generation sequencing technologies that enable the investigation of the complex interaction between host genetics and microbial communities. In this paper, we review recent studies investigating host–microbiome interactions using mGWAS. Additionally, we highlight the marked disparity in the sampling population of mGWAS carried out to date and draw attention to the critical need for inclusion of diverse populations.
topic	genome-wide association study microbiome microbiome-GWAS host-genetic host–microbiome interaction
url	https://www.frontiersin.org/article/10.3389/fgene.2018.00637/full
work_keys_str_mv	AT denisawany hostandmicrobiomegenomewideassociationstudiescurrentstateandchallenges AT imaneallali hostandmicrobiomegenomewideassociationstudiescurrentstateandchallenges AT shareefadalvie hostandmicrobiomegenomewideassociationstudiescurrentstateandchallenges AT sianhemmings hostandmicrobiomegenomewideassociationstudiescurrentstateandchallenges AT kilazasmwaikono hostandmicrobiomegenomewideassociationstudiescurrentstateandchallenges AT nicholasethomford hostandmicrobiomegenomewideassociationstudiescurrentstateandchallenges AT andresgomez hostandmicrobiomegenomewideassociationstudiescurrentstateandchallenges AT nicolamulder hostandmicrobiomegenomewideassociationstudiescurrentstateandchallenges AT emilerchimusa hostandmicrobiomegenomewideassociationstudiescurrentstateandchallenges
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Host and Microbiome Genome-Wide Association Studies: Current State and Challenges

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