Potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adults
This paper presents mechanism of action and antimicrobial spectrum of macrolides as well as the known acquired resistance mechanisms in the common pathogens causing community-acquired pneumonia, such as Streptococcus pneumoniae and Mycoplasma pneumoniae. Non-antimicrobial (anti-inflammatory and immu...
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Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
2019-12-01
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| Series: | Клиническая микробиология и антимикробная химиотерапия |
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| Online Access: | https://cmac-journal.ru/publication/2019/3/cmac-2019-t21-n3-p217/cmac-2019-t21-n3-p217.pdf |
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doaj-9269860b49aa4eeb80478b6266cfaf602020-11-25T00:57:41ZrusInterregional Association for Clinical Microbiology and Antimicrobial ChemotherapyКлиническая микробиология и антимикробная химиотерапия1684-43862686-95862019-12-0121321722310.36488/cmac.2019.3.217-223cmac-2019-t21-n3-p217Potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adultsSinopalnikov A.I.0Rachina S.A.1Zakharenkov I.A.2Russian Medical Academy of Continuous Professional Education, Moscow, RussiaRUDN University, Moscow, RussiaBryansk City HospitalThis paper presents mechanism of action and antimicrobial spectrum of macrolides as well as the known acquired resistance mechanisms in the common pathogens causing community-acquired pneumonia, such as Streptococcus pneumoniae and Mycoplasma pneumoniae. Non-antimicrobial (anti-inflammatory and immunomodulatory) effects of macrolides that have been found in experimental and clinical studies are described in detail. Results of clinical studies and current practice guidelines which determine potential benefits and a role of macrolides in the antibacterial therapy of severe community-acquired pneumonia in adults are reviewed.https://cmac-journal.ru/publication/2019/3/cmac-2019-t21-n3-p217/cmac-2019-t21-n3-p217.pdfcommunity-acquired pneumoniaantibacterial therapymacrolidesimmunomodulatory effects |
| collection |
DOAJ |
| language |
Russian |
| format |
Article |
| sources |
DOAJ |
| author |
Sinopalnikov A.I. Rachina S.A. Zakharenkov I.A. |
| spellingShingle |
Sinopalnikov A.I. Rachina S.A. Zakharenkov I.A. Potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adults Клиническая микробиология и антимикробная химиотерапия community-acquired pneumonia antibacterial therapy macrolides immunomodulatory effects |
| author_facet |
Sinopalnikov A.I. Rachina S.A. Zakharenkov I.A. |
| author_sort |
Sinopalnikov A.I. |
| title |
Potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adults |
| title_short |
Potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adults |
| title_full |
Potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adults |
| title_fullStr |
Potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adults |
| title_full_unstemmed |
Potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adults |
| title_sort |
potential for the use of macrolides in the antimicrobial therapy of severe community-acquired pneumonia in adults |
| publisher |
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy |
| series |
Клиническая микробиология и антимикробная химиотерапия |
| issn |
1684-4386 2686-9586 |
| publishDate |
2019-12-01 |
| description |
This paper presents mechanism of action and antimicrobial spectrum of macrolides as well as the known acquired resistance mechanisms in the common pathogens causing community-acquired pneumonia, such as Streptococcus pneumoniae and Mycoplasma pneumoniae. Non-antimicrobial (anti-inflammatory and immunomodulatory) effects of macrolides that have been found in experimental and clinical studies are described in detail. Results of clinical studies and current practice guidelines which determine potential benefits and a role of macrolides in the antibacterial therapy of severe community-acquired pneumonia in adults are reviewed. |
| topic |
community-acquired pneumonia antibacterial therapy macrolides immunomodulatory effects |
| url |
https://cmac-journal.ru/publication/2019/3/cmac-2019-t21-n3-p217/cmac-2019-t21-n3-p217.pdf |
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AT sinopalnikovai potentialfortheuseofmacrolidesintheantimicrobialtherapyofseverecommunityacquiredpneumoniainadults AT rachinasa potentialfortheuseofmacrolidesintheantimicrobialtherapyofseverecommunityacquiredpneumoniainadults AT zakharenkovia potentialfortheuseofmacrolidesintheantimicrobialtherapyofseverecommunityacquiredpneumoniainadults |
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1725222772215382016 |