Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling
Dry powder inhalers are often formulated by attaching micronized drug particles onto carrier particles, which are generally lactose. In this study, commercially available lactose was air jet milled to produce unique slab-like coarse carrier particles, which have larger and rougher surfaces compared...
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doaj-9270ac7dc45045679220ed943bc480db2020-11-24T23:01:35ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762017-01-01121596510.1016/j.ajps.2016.09.002Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet millingXiang Kou0Lai Wah Chan1Changquan Calvin Sun2Paul Wan Sia Heng3GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, SingaporeGEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, SingaporePharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, University of Minnesota, 308 Harvard St. SE, Minneapolis, MN 55455, USAGEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, SingaporeDry powder inhalers are often formulated by attaching micronized drug particles onto carrier particles, which are generally lactose. In this study, commercially available lactose was air jet milled to produce unique slab-like coarse carrier particles, which have larger and rougher surfaces compared to other commercially available lactose. Two key processing factors, i.e., classifier speed and jet milling pressure, were systematically investigated. The largest fraction of slab-like particles in the resulting powder was obtained at a classifier speed of 3000 rpm. The slab-like coarse carrier particles are expected to exhibit superior performance than commercial lactose due to their unique surface properties.http://www.sciencedirect.com/science/article/pii/S1818087616300897Particle engineeringShape modificationLactoseDry powder inhaler |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiang Kou Lai Wah Chan Changquan Calvin Sun Paul Wan Sia Heng |
spellingShingle |
Xiang Kou Lai Wah Chan Changquan Calvin Sun Paul Wan Sia Heng Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling Asian Journal of Pharmaceutical Sciences Particle engineering Shape modification Lactose Dry powder inhaler |
author_facet |
Xiang Kou Lai Wah Chan Changquan Calvin Sun Paul Wan Sia Heng |
author_sort |
Xiang Kou |
title |
Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling |
title_short |
Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling |
title_full |
Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling |
title_fullStr |
Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling |
title_full_unstemmed |
Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling |
title_sort |
preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling |
publisher |
Elsevier |
series |
Asian Journal of Pharmaceutical Sciences |
issn |
1818-0876 |
publishDate |
2017-01-01 |
description |
Dry powder inhalers are often formulated by attaching micronized drug particles onto carrier particles, which are generally lactose. In this study, commercially available lactose was air jet milled to produce unique slab-like coarse carrier particles, which have larger and rougher surfaces compared to other commercially available lactose. Two key processing factors, i.e., classifier speed and jet milling pressure, were systematically investigated. The largest fraction of slab-like particles in the resulting powder was obtained at a classifier speed of 3000 rpm. The slab-like coarse carrier particles are expected to exhibit superior performance than commercial lactose due to their unique surface properties. |
topic |
Particle engineering Shape modification Lactose Dry powder inhaler |
url |
http://www.sciencedirect.com/science/article/pii/S1818087616300897 |
work_keys_str_mv |
AT xiangkou preparationofslabshapedlactosecarrierparticlesfordrypowderinhalersbyairjetmilling AT laiwahchan preparationofslabshapedlactosecarrierparticlesfordrypowderinhalersbyairjetmilling AT changquancalvinsun preparationofslabshapedlactosecarrierparticlesfordrypowderinhalersbyairjetmilling AT paulwansiaheng preparationofslabshapedlactosecarrierparticlesfordrypowderinhalersbyairjetmilling |
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1725638952038170624 |