The effect of ethanol extract of ylang-ylang flower (Cananga odorata) on vascular and kidney histology in menopausal mice

• Main Authors: Juliastuti Juliastuti, Ampera Miko, Nurlaili Ramli, Emilda Emilda, Lia Lajuna, Cut Yuniwati, Fithriany Fithriany, Anita Anita, Yuni Sari, Nora Veri
• Format: Article
• Language: English
• Published: Elsevier 2017-10-01
• Series: Clinical Nutrition Experimental
• Subjects: Menopause; Vascular; Renal; Herbal; Toxicity
• Online Access: http://www.sciencedirect.com/science/article/pii/S2352939317300271

This study aimed to evaluate the histopathological changes in the aorta and kidneys of mice age of menopause by the ethanol extract of ylang-ylang (Cananga odorata) flowers. Thirty female age of menopause mice was divided into three groups (n = 10 each group), consisting of a group of mice the age of menopause without any treatment, mice age of menopause treated with different dosages of ylang-ylang flower extract (0.1 mg/day and 0.2 mg/day). Histopathological analysis was performed with hematoxylin-eosin staining. The number of endothelial cells and the thickness of the intima in the group treated with high dose of the extract were significantly higher than the lowest dose of the extract or the control group (p < 0.05). The diameter of the Bowman's capsule and the renal glomerulus was significantly higher in the group treated with ylang-ylang flower extract compared with the control group (p < 0.05). Concluded that at the doses administered, ylang flower extract triggers the repair of endothelial cells, but increase the thickness of the intima and hyperplasia of the kidney in mice age of menopause. Thus, ylang flower extract and renal vascular remodeling triggered by the age of menopause.