Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles
ABSTRACT<br /> In this paper the synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Ethyl methacrylate was treated with hydrazine hydrate in ethanol to give the corresponding hydrazide (1). The hydrazide was converted to 1-acyl thiosemicarbazid...
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College of Education for Pure Sciences
2009-06-01
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doaj-927976085bae40ac9c1ab74dc2f6bf772020-11-25T00:32:50ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302009-06-01222293710.33899/edusj.2009.5768657686Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazolesShereen R. MohamedABSTRACT<br /> In this paper the synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Ethyl methacrylate was treated with hydrazine hydrate in ethanol to give the corresponding hydrazide (1). The hydrazide was converted to 1-acyl thiosemicarbazide (2) byits reaction with ammonium thiocyanate, which was treated with sodium hydroxide solution and with concentrated sulfuric acid to give 5-substituted-1,2,4-triazoles-3-thiol (3) and 2-substituted-5-amino-1,3,4-thiadiazole (4) respectively. The acid hydrazide (1) was treated with benzaldehyde or substituted benzaldehyde to give hydrazones (7-12), the hydrazones were then cyclized with lead dioxide to 2-subtituted-5-phenyl 1,3,4-oxadiazole (14). The reaction of the hydrazide (1) with formic acid gave 1-formyl-2-acyl hydrazine (6) and the cyclization of (6) by phosphorus pentaoxide gave monosubstituted-1,3,4-oxadiazoles (13). Acid hydrazide (1) was treated with phenyl isothiocyanate to give substituted thiosemicarbazide (5).https://edusj.mosuljournals.com/article_57686_9cab6a19e0184b37ecb607fda0d4368f.pdfsynthesis34-oxadiazolesthiadiazoles124-triazoles |
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DOAJ |
language |
Arabic |
format |
Article |
sources |
DOAJ |
author |
Shereen R. Mohamed |
spellingShingle |
Shereen R. Mohamed Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles مجلة التربية والعلم synthesis 3 4-oxadiazoles thiadiazoles 1 2 4-triazoles |
author_facet |
Shereen R. Mohamed |
author_sort |
Shereen R. Mohamed |
title |
Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles |
title_short |
Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles |
title_full |
Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles |
title_fullStr |
Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles |
title_full_unstemmed |
Synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles |
title_sort |
synthesis of some substituted 1,3,4-oxadiazoles, thiadiazoles and 1,2,4-triazoles |
publisher |
College of Education for Pure Sciences |
series |
مجلة التربية والعلم |
issn |
1812-125X 2664-2530 |
publishDate |
2009-06-01 |
description |
ABSTRACT<br /> In this paper the synthesis of some substituted 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles is reported. Ethyl methacrylate was treated with hydrazine hydrate in ethanol to give the corresponding hydrazide (1). The hydrazide was converted to 1-acyl thiosemicarbazide (2) byits reaction with ammonium thiocyanate, which was treated with sodium hydroxide solution and with concentrated sulfuric acid to give 5-substituted-1,2,4-triazoles-3-thiol (3) and 2-substituted-5-amino-1,3,4-thiadiazole (4) respectively. The acid hydrazide (1) was treated with benzaldehyde or substituted benzaldehyde to give hydrazones (7-12), the hydrazones were then cyclized with lead dioxide to 2-subtituted-5-phenyl 1,3,4-oxadiazole (14). The reaction of the hydrazide (1) with formic acid gave 1-formyl-2-acyl hydrazine (6) and the cyclization of (6) by phosphorus pentaoxide gave monosubstituted-1,3,4-oxadiazoles (13). Acid hydrazide (1) was treated with phenyl isothiocyanate to give substituted thiosemicarbazide (5). |
topic |
synthesis 3 4-oxadiazoles thiadiazoles 1 2 4-triazoles |
url |
https://edusj.mosuljournals.com/article_57686_9cab6a19e0184b37ecb607fda0d4368f.pdf |
work_keys_str_mv |
AT shereenrmohamed synthesisofsomesubstituted134oxadiazolesthiadiazolesand124triazoles |
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1725318821094359040 |