Evaluation of Serum Pregnancy Associated Plasma Protein-A & Plasma D-Dimer in Acute Coronary Syndrome
Introduction: Acute coronary syndrome (ACS), a spectrum comprising unstable angina pectoris, ST Elevated Myocardial Infarction (STEMI) & Non ST Elevated Myocardial Infarction (NSTEMI) is the major cause of presentation in Emergency Department today. Though ECG and cardiac enzymes are used f...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2016-01-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/7011/14432_CE[Ra1]_F(GH)_PF1(Bm_Om)_PFA(P)_PF2(PAG).pdf |
Summary: | Introduction: Acute coronary syndrome (ACS), a spectrum
comprising unstable angina pectoris, ST Elevated Myocardial
Infarction (STEMI) & Non ST Elevated Myocardial Infarction
(NSTEMI) is the major cause of presentation in Emergency
Department today. Though ECG and cardiac enzymes are
used for diagnosis, they mislead the diagnosis sometimes and
delay in treatment initiation. This leads us to search certain new
parameters which reflect the pathophysiology of ACS. Markers
of plaque stability like Pregnancy Associated Plasma Protein-A
and D-Dimer, a marker of ongoing thrombosis are found to be
better markers in early diagnosis.
Aim: To evaluate the diagnostic competence of PAPP-A and
D-Dimer in acute coronary syndrome over CK-MB and to compare
with the inflammatory marker High Sensitive C-Reactive Protein
(hs-CRP) which is associated with atherosclerosis.
Materials and Methods: Fifty patients presenting with acute
onset of chest pain to Emergency Department with or without
ECG changes served as cases and 50 healthy people served
as controls. Serum PAPP-A is measured by Enzyme Linked
Immunosorbent Assay (ELISA), D-Dimer and hs-CRP by using
Latex Turbidimetry method.
Results: A statistical significant difference of PAPP-A and
D-Dimer was noted between the ACS and controls (p < 0.001)
whereas CK-MB shows no much difference (p 0.09). Statistically
significant positive correlation is noted between parameters.
Conclusion: PAPP-A marker of plaque instability and D-Dimer
marker of ongoing thrombosis are raised in acute coronary
syndrome and thus can be considered as one of the marker in
ACS for diagnosis. |
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ISSN: | 2249-782X 0973-709X |