Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence

Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence

In the last couple of decades, there has been a growing optimism surrounding the potential transformative use of human mesenchymal stem cells (MSCs) and human-induced pluripotent stem cells (iPSCs) for regenerative medicine and disease treatment. In order for this to occur, it is first essential to...

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Bibliographic Details
Main Authors: Qing Shao, Jessica L. Esseltine, Tao Huang, Nicole Novielli-Kuntz, Jamie E. Ching, Jacinda Sampson, Dale W. Laird
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
mesenchymal stem cells
adipogenesis
connexin43
gap junctional intercellular communication
oculodentodigital dysplasia
senescence
CRISPR-Cas9
Online Access:https://www.mdpi.com/2218-273X/9/9/474

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