Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity

Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity

Carbonyl iron powder (CIP) has been used as a food additive or mineral supplement. However, the effects of CIP on iron deficiency anemia (IDA) and its subchronic toxicity have not been investigated. We found that oral administration of CIP at a dose of 2.96 mg/kg recovered the hemoglobin concentrati...

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Main Authors: Qiaosha Zhu, Yang Qian, Ying Yang, Weifeng Wu, Jingli Xie, Dongzhi Wei
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Journal of Food and Drug Analysis
Subjects:
carbonyl iron powder
iron deficiency anemia
iron supplements
subchronic toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S1021949816300473
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spelling doaj-92aeb124099f4519a6a70c0499fc889a2020-11-25T00:28:32ZengElsevierJournal of Food and Drug Analysis1021-94982016-10-0124474675310.1016/j.jfda.2016.04.003Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicityQiaosha Zhu0Yang Qian1Ying Yang2Weifeng Wu3Jingli Xie4Dongzhi Wei5State Key Laboratory of Bioreactor Engineering, Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, ChinaDepartment of Radiotherapy of Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaState Key Laboratory of Bioreactor Engineering, Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Bioreactor Engineering, Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Bioreactor Engineering, Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Bioreactor Engineering, Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, ChinaCarbonyl iron powder (CIP) has been used as a food additive or mineral supplement. However, the effects of CIP on iron deficiency anemia (IDA) and its subchronic toxicity have not been investigated. We found that oral administration of CIP at a dose of 2.96 mg/kg recovered the hemoglobin concentration of erythrocytes of IDA rats to the normal level after 8 days. The no observed adverse effect level of CIP in rats was considered to be > 200 mg/kg. The hematological and serum biochemical parameters of the rats did not differ significantly between the control and treated groups. There were no morphological changes observed in the organs including liver, kidneys, spleen, testes, stomach and intestine. Therefore, CIP might be a safe iron supplement.http://www.sciencedirect.com/science/article/pii/S1021949816300473carbonyl iron powderiron deficiency anemiairon supplementssubchronic toxicity
collection DOAJ
language English
format Article
sources DOAJ
author Qiaosha Zhu
Yang Qian
Ying Yang
Weifeng Wu
Jingli Xie
Dongzhi Wei
spellingShingle Qiaosha Zhu
Yang Qian
Ying Yang
Weifeng Wu
Jingli Xie
Dongzhi Wei
Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
Journal of Food and Drug Analysis
carbonyl iron powder
iron deficiency anemia
iron supplements
subchronic toxicity
author_facet Qiaosha Zhu
Yang Qian
Ying Yang
Weifeng Wu
Jingli Xie
Dongzhi Wei
author_sort Qiaosha Zhu
title Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title_short Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title_full Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title_fullStr Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title_full_unstemmed Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
title_sort effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity
publisher Elsevier
series Journal of Food and Drug Analysis
issn 1021-9498
publishDate 2016-10-01
description Carbonyl iron powder (CIP) has been used as a food additive or mineral supplement. However, the effects of CIP on iron deficiency anemia (IDA) and its subchronic toxicity have not been investigated. We found that oral administration of CIP at a dose of 2.96 mg/kg recovered the hemoglobin concentration of erythrocytes of IDA rats to the normal level after 8 days. The no observed adverse effect level of CIP in rats was considered to be > 200 mg/kg. The hematological and serum biochemical parameters of the rats did not differ significantly between the control and treated groups. There were no morphological changes observed in the organs including liver, kidneys, spleen, testes, stomach and intestine. Therefore, CIP might be a safe iron supplement.
topic carbonyl iron powder
iron deficiency anemia
iron supplements
subchronic toxicity
url http://www.sciencedirect.com/science/article/pii/S1021949816300473
work_keys_str_mv AT qiaoshazhu effectsofcarbonylironpowderonirondeficiencyanemiaanditssubchronictoxicity
AT yangqian effectsofcarbonylironpowderonirondeficiencyanemiaanditssubchronictoxicity
AT yingyang effectsofcarbonylironpowderonirondeficiencyanemiaanditssubchronictoxicity
AT weifengwu effectsofcarbonylironpowderonirondeficiencyanemiaanditssubchronictoxicity
AT jinglixie effectsofcarbonylironpowderonirondeficiencyanemiaanditssubchronictoxicity
AT dongzhiwei effectsofcarbonylironpowderonirondeficiencyanemiaanditssubchronictoxicity
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