Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration

The brains of Alzheimer’s disease patients show a decrease in brain mass and a preponderance of extracellular Amyloid-β plaques. These plaques are formed by aggregation of polypeptides that are derived from the Amyloid Precursor Protein (APP). Amyloid-β plaques are thought to play either a direct or...

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Bibliographic Details
Main Authors: Chu Hsien Lim, Prameet Kaur, Emelyne Teo, Vanessa Yuk Man Lam, Fangchen Zhu, Caroline Kibat, Jan Gruber, Ajay S Mathuru, Nicholas S Tolwinski
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/52589