Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration
The brains of Alzheimer’s disease patients show a decrease in brain mass and a preponderance of extracellular Amyloid-β plaques. These plaques are formed by aggregation of polypeptides that are derived from the Amyloid Precursor Protein (APP). Amyloid-β plaques are thought to play either a direct or...
Main Authors: | Chu Hsien Lim, Prameet Kaur, Emelyne Teo, Vanessa Yuk Man Lam, Fangchen Zhu, Caroline Kibat, Jan Gruber, Ajay S Mathuru, Nicholas S Tolwinski |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/52589 |
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