Mechanisms of Apoptosis Resistance to NK Cell-Mediated Cytotoxicity in Cancer

Mechanisms of Apoptosis Resistance to NK Cell-Mediated Cytotoxicity in Cancer

Natural killer (NK) cells are major contributors to immunosurveillance and control of tumor development by inducing apoptosis of malignant cells. Among the main mechanisms involved in NK cell-mediated cytotoxicity, the death receptor pathway and the release of granules containing perforin/granzymes...

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Bibliographic Details
Main Authors: Christian Sordo-Bahamonde, Seila Lorenzo-Herrero, Ángel R. Payer, Segundo Gonzalez, Alejandro López-Soto
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
NK cell
apoptosis
granzymes
perforin
death receptors
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Online Access:https://www.mdpi.com/1422-0067/21/10/3726

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