Physiological Roles of ERM Proteins and Transcriptional Regulators in Supporting Membrane Expression of Efflux Transporters as Factors of Drug Resistance in Cancer

Physiological Roles of ERM Proteins and Transcriptional Regulators in Supporting Membrane Expression of Efflux Transporters as Factors of Drug Resistance in Cancer

One factor contributing to the malignancy of cancer cells is the acquisition of drug resistance during chemotherapy via increased expression of efflux transporters, such as P-glycoprotein (P-gp), multidrug resistance-associated proteins (MRPs), and breast cancer resistance protein (BCRP). These tran...

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Bibliographic Details
Main Authors: Takuo Ogihara, Kenta Mizoi, Hiroki Kamioka, Kentaro Yano
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
efflux transporters
ERM proteins
transcriptional regulators
SNAI family
epithelial–mesenchymal transition
membrane expression
Online Access:https://www.mdpi.com/2072-6694/12/11/3352

Internet

https://www.mdpi.com/2072-6694/12/11/3352

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