Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity

Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity

Objective: Patient-derived xenograft (PDX) models have shown great promise in preclinical and translational applications, but their consistency with primary tumors in phenotypic, genetic, and pharmacodynamic heterogeneity has not been well-studied. This study aimed to establish a PDX repository for...

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Bibliographic Details
Main Authors: Xuanming Chen, Cheng Shen, Zhe Wei, Rui Zhang, Yongsheng Wang, Lili Jiang, Ke Chen, Shuang Qiu, Yuanli Zhang, Ting Zhang, Bin Chen, Yanjun Xu, Qiyi Feng, Jinxing Huang, Zhihui Zhong, Hongxia Li, Guowei Che, Kai Xiao
Format: Article
Language:English
Published: China Anti-Cancer Association 2021-02-01
Series:Cancer Biology & Medicine
Subjects:
patient-derived xenograft (pdx)
non-small cell lung cancer (nsclc)
tumor heterogeneity
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1779

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