Lipase catalyzed synthesis of antimicrobial andrographolide derivatives

Lipase catalyzed synthesis of antimicrobial andrographolide derivatives

In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compoun...

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Main Authors: Harshal S. Patil, Dipesh D. Jadhav, Ajay Paul, Fayaj A. Mulani, Shrikant J. Karegaonkar, Hirekodathakallu V. Thulasiram
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340918303160
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spelling doaj-92dee17b5d794399b4c12a1b8f4eba852020-11-25T00:47:16ZengElsevierData in Brief2352-34092018-06-011811341141Lipase catalyzed synthesis of antimicrobial andrographolide derivativesHarshal S. Patil0Dipesh D. Jadhav1Ajay Paul2Fayaj A. Mulani3Shrikant J. Karegaonkar4Hirekodathakallu V. Thulasiram5Chemical Biology Unit, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411008, IndiaChemical Biology Unit, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411008, IndiaChemical Biology Unit, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411008, IndiaChemical Biology Unit, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411008, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, IndiaChemical Biology Unit, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411008, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, IndiaChemical Biology Unit, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411008, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, India; CSIR-Institute of Genomics and Integrative Biology, Mall Road, New Delhi 110007, India; Corresponding author.In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compounds, andrographolide-14-propionate and andrographolide-14-caproate were characterized by various spectral studies. These two derivatives showed more antimicrobial activity than andrographolide. Keywords: Andrographolide, Lipase, Antimicrobialhttp://www.sciencedirect.com/science/article/pii/S2352340918303160
collection DOAJ
language English
format Article
sources DOAJ
author Harshal S. Patil
Dipesh D. Jadhav
Ajay Paul
Fayaj A. Mulani
Shrikant J. Karegaonkar
Hirekodathakallu V. Thulasiram
spellingShingle Harshal S. Patil
Dipesh D. Jadhav
Ajay Paul
Fayaj A. Mulani
Shrikant J. Karegaonkar
Hirekodathakallu V. Thulasiram
Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
Data in Brief
author_facet Harshal S. Patil
Dipesh D. Jadhav
Ajay Paul
Fayaj A. Mulani
Shrikant J. Karegaonkar
Hirekodathakallu V. Thulasiram
author_sort Harshal S. Patil
title Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title_short Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title_full Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title_fullStr Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title_full_unstemmed Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title_sort lipase catalyzed synthesis of antimicrobial andrographolide derivatives
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2018-06-01
description In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compounds, andrographolide-14-propionate and andrographolide-14-caproate were characterized by various spectral studies. These two derivatives showed more antimicrobial activity than andrographolide. Keywords: Andrographolide, Lipase, Antimicrobial
url http://www.sciencedirect.com/science/article/pii/S2352340918303160
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