Role of CMR Mapping Techniques in Cardiac Hypertrophic Phenotype
Non-ischemic cardiomyopathies represent a heterogeneous group of myocardial diseases potentially leading to heart failure, life-threatening arrhythmias, and eventually death. Myocardial dysfunction is associated with different underlying pathological processes, ultimately inducing changes in morphol...
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Format: | Article |
Language: | English |
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MDPI AG
2020-09-01
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Series: | Diagnostics |
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Online Access: | https://www.mdpi.com/2075-4418/10/10/770 |
id |
doaj-92e8991260654b5a93fa090a50edc26b |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea Baggiano Alberico Del Torto Marco Guglielmo Giuseppe Muscogiuri Laura Fusini Mario Babbaro Ada Collevecchio Rocco Mollace Stefano Scafuri Saima Mushtaq Edoardo Conte Andrea Daniele Annoni Alberto Formenti Maria Elisabetta Mancini Giulia Mostardini Daniele Andreini Andrea Igoren Guaricci Mauro Pepi Marianna Fontana Gianluca Pontone |
spellingShingle |
Andrea Baggiano Alberico Del Torto Marco Guglielmo Giuseppe Muscogiuri Laura Fusini Mario Babbaro Ada Collevecchio Rocco Mollace Stefano Scafuri Saima Mushtaq Edoardo Conte Andrea Daniele Annoni Alberto Formenti Maria Elisabetta Mancini Giulia Mostardini Daniele Andreini Andrea Igoren Guaricci Mauro Pepi Marianna Fontana Gianluca Pontone Role of CMR Mapping Techniques in Cardiac Hypertrophic Phenotype Diagnostics cardiovascular magnetic resonance non-ischemic cardiomyopathies hypertrophic phenotype T1 mapping T2 mapping ECV mapping |
author_facet |
Andrea Baggiano Alberico Del Torto Marco Guglielmo Giuseppe Muscogiuri Laura Fusini Mario Babbaro Ada Collevecchio Rocco Mollace Stefano Scafuri Saima Mushtaq Edoardo Conte Andrea Daniele Annoni Alberto Formenti Maria Elisabetta Mancini Giulia Mostardini Daniele Andreini Andrea Igoren Guaricci Mauro Pepi Marianna Fontana Gianluca Pontone |
author_sort |
Andrea Baggiano |
title |
Role of CMR Mapping Techniques in Cardiac Hypertrophic Phenotype |
title_short |
Role of CMR Mapping Techniques in Cardiac Hypertrophic Phenotype |
title_full |
Role of CMR Mapping Techniques in Cardiac Hypertrophic Phenotype |
title_fullStr |
Role of CMR Mapping Techniques in Cardiac Hypertrophic Phenotype |
title_full_unstemmed |
Role of CMR Mapping Techniques in Cardiac Hypertrophic Phenotype |
title_sort |
role of cmr mapping techniques in cardiac hypertrophic phenotype |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-09-01 |
description |
Non-ischemic cardiomyopathies represent a heterogeneous group of myocardial diseases potentially leading to heart failure, life-threatening arrhythmias, and eventually death. Myocardial dysfunction is associated with different underlying pathological processes, ultimately inducing changes in morphological appearance. Thus, classification based on presenting morphological phenotypes has been proposed, i.e., dilated, hypertrophic, restrictive, and right ventricular cardiomyopathies. In light of the key diagnostic and prognostic role of morphological and functional features, cardiovascular imaging has emerged as key element in the clinical workflow of suspected cardiomyopathies, and above all, cardiovascular magnetic resonance (CMR) represents the ideal technique to be used: thanks to its physical principles, besides optimal spatial and temporal resolutions, incomparable contrast resolution allows to assess myocardial tissue abnormalities in detail. Traditionally, weighted images and late enhancement images after gadolinium-based contrast agent administration have been used to perform tissue characterization, but in the last decade quantitative assessment of pre-contrast longitudinal relaxation time (native T1), post-contrast longitudinal relaxation time (post-contrast T1) and transversal relaxation time (T2), all displayed with dedicated pixel-wise color-coded maps (mapping), has contributed to give precious knowledge insight, with positive influence of diagnostic accuracy and prognosis assessment, mostly in the setting of the hypertrophic phenotype. This review aims to describe the available evidence of the role of mapping techniques in the assessment of hypertrophic phenotype, and to suggest their integration in the routine CMR evaluation of newly diagnosed cardiomyopathies with increased wall thickness. |
topic |
cardiovascular magnetic resonance non-ischemic cardiomyopathies hypertrophic phenotype T1 mapping T2 mapping ECV mapping |
url |
https://www.mdpi.com/2075-4418/10/10/770 |
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doaj-92e8991260654b5a93fa090a50edc26b2020-11-25T03:55:38ZengMDPI AGDiagnostics2075-44182020-09-011077077010.3390/diagnostics10100770Role of CMR Mapping Techniques in Cardiac Hypertrophic PhenotypeAndrea Baggiano0Alberico Del Torto1Marco Guglielmo2Giuseppe Muscogiuri3Laura Fusini4Mario Babbaro5Ada Collevecchio6Rocco Mollace7Stefano Scafuri8Saima Mushtaq9Edoardo Conte10Andrea Daniele Annoni11Alberto Formenti12Maria Elisabetta Mancini13Giulia Mostardini14Daniele Andreini15Andrea Igoren Guaricci16Mauro Pepi17Marianna Fontana18Gianluca Pontone19Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyDipartimento di Medicina Clinica e Molecolare, Facoltà di Medicina e Psicologia, Università degli Studi di Roma “Sapienza”—Azienda Ospedaliera Sant’Andrea, 00189 Rome, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiology, University of Rome Tor Vergata, 00133 Rome, ItalyCardiothoracovascular Department, University of Florence, Azienda Ospedaliero-Universitaria Careggi, 50139 Florence, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyInstitute of Cardiovascular Disease, Department of Emergency and Organ Transplantation, University Hospital Policlinico of Bari, 70124 Bari, ItalyCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyNational Amyloidosis Centre, Division of Medicine, University College London, Royal Free Hospital, London NW3 2PF, UKCardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, 20138 Milan, ItalyNon-ischemic cardiomyopathies represent a heterogeneous group of myocardial diseases potentially leading to heart failure, life-threatening arrhythmias, and eventually death. Myocardial dysfunction is associated with different underlying pathological processes, ultimately inducing changes in morphological appearance. Thus, classification based on presenting morphological phenotypes has been proposed, i.e., dilated, hypertrophic, restrictive, and right ventricular cardiomyopathies. In light of the key diagnostic and prognostic role of morphological and functional features, cardiovascular imaging has emerged as key element in the clinical workflow of suspected cardiomyopathies, and above all, cardiovascular magnetic resonance (CMR) represents the ideal technique to be used: thanks to its physical principles, besides optimal spatial and temporal resolutions, incomparable contrast resolution allows to assess myocardial tissue abnormalities in detail. Traditionally, weighted images and late enhancement images after gadolinium-based contrast agent administration have been used to perform tissue characterization, but in the last decade quantitative assessment of pre-contrast longitudinal relaxation time (native T1), post-contrast longitudinal relaxation time (post-contrast T1) and transversal relaxation time (T2), all displayed with dedicated pixel-wise color-coded maps (mapping), has contributed to give precious knowledge insight, with positive influence of diagnostic accuracy and prognosis assessment, mostly in the setting of the hypertrophic phenotype. This review aims to describe the available evidence of the role of mapping techniques in the assessment of hypertrophic phenotype, and to suggest their integration in the routine CMR evaluation of newly diagnosed cardiomyopathies with increased wall thickness.https://www.mdpi.com/2075-4418/10/10/770cardiovascular magnetic resonancenon-ischemic cardiomyopathieshypertrophic phenotypeT1 mappingT2 mappingECV mapping |