Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
Innate immunity sensors are expressed by both tumour cells and tumour-associated myeloid cells. Here, the authors show that stimulation of the innate immunity response with pseudoviruses in a genetic mouse model of intestinal cancer triggers tumour regression via Caspase-1 activation.
Main Authors: | Zhenyu Zhong, Yougang Zhai, Ping Bu, Shivanee Shah, Liang Qiao |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-04-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms15004 |
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