Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region

Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region

Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variant...

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Main Authors: Darlen Cardoso Carvalho, Alayde Vieira Wanderley, Fernando Augusto Rodrigues Mello Junior, Junior, André Mauricio Ribeiro dos Santos, Luciana Pereira Colares Leitão, Tatiane Piedade de Souza, Amanda de Nazaré Cohen Lima de Castro, Leandro Lopes de Magalhães, Marianne Rodrigues Fernandes, João Augusto Nunes de Carvalho Junior, Junior, André Salim Khayat, Sidney Santos, Paulo Pimentel de Assumpção, Ney Pereira Carneiro dos Santos
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Leukemia Research Reports
Subjects:
ALL
Pediatrics
Polymorphisms
Susceptibility
Admixed
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048919300512
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spelling doaj-92ec92044e5044f19cd7a41bced566652020-11-25T02:48:58ZengElsevierLeukemia Research Reports2213-04892020-01-0113100188Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon regionDarlen Cardoso Carvalho0Alayde Vieira Wanderley1Fernando Augusto Rodrigues Mello Junior, Junior2André Mauricio Ribeiro dos Santos3Luciana Pereira Colares Leitão4Tatiane Piedade de Souza5Amanda de Nazaré Cohen Lima de Castro6Leandro Lopes de Magalhães7Marianne Rodrigues Fernandes8João Augusto Nunes de Carvalho Junior, Junior9André Salim Khayat10Sidney Santos11Paulo Pimentel de Assumpção12Ney Pereira Carneiro dos Santos13Núcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil; Hospital Ophir Loyola, Departamento de Pediatria, Avenida Governador Magalhães Barata, 992, Belém, Pará CEP 66060-281, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, BrazilLaboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Cidade Universitária Prof. José Silveira Netto, Belém, Pará 01 - CEP 66075-900, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, BrazilLaboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Cidade Universitária Prof. José Silveira Netto, Belém, Pará 01 - CEP 66075-900, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil; Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Cidade Universitária Prof. José Silveira Netto, Belém, Pará 01 - CEP 66075-900, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil; Hospital Universitário João de Barros Barreto, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, BrazilNúcleo de Pesquisas em Oncologia, Rua dos Mundurucus, 4487, Belém, Pará CEP 66073-000, Brazil; Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Cidade Universitária Prof. José Silveira Netto, Belém, Pará 01 - CEP 66075-900, Brazil; Corresponding author at: Rua dos Mundurucus, 4487, Guamá, Belém, PA, Brazil.Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population.http://www.sciencedirect.com/science/article/pii/S2213048919300512ALLPediatricsPolymorphismsSusceptibilityAdmixed
collection DOAJ
language English
format Article
sources DOAJ
author Darlen Cardoso Carvalho
Alayde Vieira Wanderley
Fernando Augusto Rodrigues Mello Junior, Junior
André Mauricio Ribeiro dos Santos
Luciana Pereira Colares Leitão
Tatiane Piedade de Souza
Amanda de Nazaré Cohen Lima de Castro
Leandro Lopes de Magalhães
Marianne Rodrigues Fernandes
João Augusto Nunes de Carvalho Junior, Junior
André Salim Khayat
Sidney Santos
Paulo Pimentel de Assumpção
Ney Pereira Carneiro dos Santos
spellingShingle Darlen Cardoso Carvalho
Alayde Vieira Wanderley
Fernando Augusto Rodrigues Mello Junior, Junior
André Mauricio Ribeiro dos Santos
Luciana Pereira Colares Leitão
Tatiane Piedade de Souza
Amanda de Nazaré Cohen Lima de Castro
Leandro Lopes de Magalhães
Marianne Rodrigues Fernandes
João Augusto Nunes de Carvalho Junior, Junior
André Salim Khayat
Sidney Santos
Paulo Pimentel de Assumpção
Ney Pereira Carneiro dos Santos
Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
Leukemia Research Reports
ALL
Pediatrics
Polymorphisms
Susceptibility
Admixed
author_facet Darlen Cardoso Carvalho
Alayde Vieira Wanderley
Fernando Augusto Rodrigues Mello Junior, Junior
André Mauricio Ribeiro dos Santos
Luciana Pereira Colares Leitão
Tatiane Piedade de Souza
Amanda de Nazaré Cohen Lima de Castro
Leandro Lopes de Magalhães
Marianne Rodrigues Fernandes
João Augusto Nunes de Carvalho Junior, Junior
André Salim Khayat
Sidney Santos
Paulo Pimentel de Assumpção
Ney Pereira Carneiro dos Santos
author_sort Darlen Cardoso Carvalho
title Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title_short Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title_full Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title_fullStr Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title_full_unstemmed Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region
title_sort association of genes arid5b, cebpe and folate pathway with acute lymphoblastic leukemia in a population from the brazilian amazon region
publisher Elsevier
series Leukemia Research Reports
issn 2213-0489
publishDate 2020-01-01
description Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population.
topic ALL
Pediatrics
Polymorphisms
Susceptibility
Admixed
url http://www.sciencedirect.com/science/article/pii/S2213048919300512
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