Molecular signaling mechanisms that mediate exercise training effects on insulin sensitivity
Studies on exercise-induced stimulation of glucose uptake into skeletal muscle have indicated that components of the insulin signal transduction system, such as insulin receptor, IRS-1, and PI 3-kinase, are not involved in the mechanism of glucose uptake elicited by an acute bout of exercise, sugges...
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Japanese Society of Physical Fitness and Sports Medicine
2013-04-01
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doaj-92f0ac6cd72d4b7189ff837d483b0e042021-05-31T06:21:08ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232013-04-012111711910.7600/jpfsm.2.117jpfsmMolecular signaling mechanisms that mediate exercise training effects on insulin sensitivityMasaru Nagasaki0Yoshiharu Shimomura1Yuzo Sato2Department of Health Science, Faculty of Psychological & Physical Science, Aichi Gakuin UniversityDepartment of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya UniversityDepartment of Health Science, Faculty of Psychological & Physical Science, Aichi Gakuin UniversityStudies on exercise-induced stimulation of glucose uptake into skeletal muscle have indicated that components of the insulin signal transduction system, such as insulin receptor, IRS-1, and PI 3-kinase, are not involved in the mechanism of glucose uptake elicited by an acute bout of exercise, suggesting that the underlying molecular mechanism, by which an acute bout of exercise increases glucose uptake, is distinct from that of insulin. Sedentarism, maturation and dietary factors such as high-fat feeding cause insulin resistance, which is a result of defective signal transduction. On the other hand, exercise training and calorie restriction improve and prevent insulin resistance. The exercise training effects represented by improved insulin action in vivo are chiefly attributed to changes in body composition factors such as increased muscle volume and decreased body fat, and changes in post-insulin receptor mechanisms.https://www.jstage.jst.go.jp/article/jpfsm/2/1/2_117/_pdf/-char/eninsulin sensitivityexercise trainingskeletal muscleglucose uptakeobesity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masaru Nagasaki Yoshiharu Shimomura Yuzo Sato |
spellingShingle |
Masaru Nagasaki Yoshiharu Shimomura Yuzo Sato Molecular signaling mechanisms that mediate exercise training effects on insulin sensitivity Journal of Physical Fitness and Sports Medicine insulin sensitivity exercise training skeletal muscle glucose uptake obesity |
author_facet |
Masaru Nagasaki Yoshiharu Shimomura Yuzo Sato |
author_sort |
Masaru Nagasaki |
title |
Molecular signaling mechanisms that mediate exercise training effects on insulin sensitivity |
title_short |
Molecular signaling mechanisms that mediate exercise training effects on insulin sensitivity |
title_full |
Molecular signaling mechanisms that mediate exercise training effects on insulin sensitivity |
title_fullStr |
Molecular signaling mechanisms that mediate exercise training effects on insulin sensitivity |
title_full_unstemmed |
Molecular signaling mechanisms that mediate exercise training effects on insulin sensitivity |
title_sort |
molecular signaling mechanisms that mediate exercise training effects on insulin sensitivity |
publisher |
Japanese Society of Physical Fitness and Sports Medicine |
series |
Journal of Physical Fitness and Sports Medicine |
issn |
2186-8131 2186-8123 |
publishDate |
2013-04-01 |
description |
Studies on exercise-induced stimulation of glucose uptake into skeletal muscle have indicated that components of the insulin signal transduction system, such as insulin receptor, IRS-1, and PI 3-kinase, are not involved in the mechanism of glucose uptake elicited by an acute bout of exercise, suggesting that the underlying molecular mechanism, by which an acute bout of exercise increases glucose uptake, is distinct from that of insulin. Sedentarism, maturation and dietary factors such as high-fat feeding cause insulin resistance, which is a result of defective signal transduction. On the other hand, exercise training and calorie restriction improve and prevent insulin resistance. The exercise training effects represented by improved insulin action in vivo are chiefly attributed to changes in body composition factors such as increased muscle volume and decreased body fat, and changes in post-insulin receptor mechanisms. |
topic |
insulin sensitivity exercise training skeletal muscle glucose uptake obesity |
url |
https://www.jstage.jst.go.jp/article/jpfsm/2/1/2_117/_pdf/-char/en |
work_keys_str_mv |
AT masarunagasaki molecularsignalingmechanismsthatmediateexercisetrainingeffectsoninsulinsensitivity AT yoshiharushimomura molecularsignalingmechanismsthatmediateexercisetrainingeffectsoninsulinsensitivity AT yuzosato molecularsignalingmechanismsthatmediateexercisetrainingeffectsoninsulinsensitivity |
_version_ |
1721419404589137920 |