Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis
Extensively drug-resistant tuberculosis (XDR TB) has extremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifestations, treatment, and outcomes for 37 children (<15 years of age) with bacteriologically confirmed XDR TB in 11 countries. Thes...
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2019-03-01
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Online Access: | https://wwwnc.cdc.gov/eid/article/25/3/18-0852_article |
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doaj-92f352615fe24d6787c5887e0c07cc982020-11-25T01:11:55ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592019-03-0125344145010.3201/eid2503.180852Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant TuberculosisMuhammad OsmanElizabeth P. HarauszAnthony J. Garcia-PratsH. Simon SchaafBrittany K. MooreRobert M. HicksJay AcharFarhana AmanullahPennan BarryMercedes BecerraDomnica I. ChiotanPeter C. DrobacJennifer FloodJennifer FurinMedea GegiaPetros IsaakidisAndrei MariandyshevIveta OzereN. Sarita ShahAlena SkrahinaElena YablokovaJames A. SeddonAnneke C. HesselingExtensively drug-resistant tuberculosis (XDR TB) has extremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifestations, treatment, and outcomes for 37 children (<15 years of age) with bacteriologically confirmed XDR TB in 11 countries. These patients were managed during 1999–2013. For the 37 children, median age was 11 years, 32 (87%) had pulmonary TB, and 29 had a recorded HIV status; 7 (24%) were infected with HIV. Median treatment duration was 7.0 months for the intensive phase and 12.2 months for the continuation phase. Thirty (81%) children had favorable treatment outcomes. Four (11%) died, 1 (3%) failed treatment, and 2 (5%) did not complete treatment. We found a high proportion of favorable treatment outcomes among children, with mortality rates markedly lower than for adults. Regimens and duration of treatment varied considerably. Evaluation of new regimens in children is required.https://wwwnc.cdc.gov/eid/article/25/3/18-0852_articletuberculosis and other mycobacteriatuberculosisTBextensively drug-resistant tuberculosisXDR TBantimicrobial resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Muhammad Osman Elizabeth P. Harausz Anthony J. Garcia-Prats H. Simon Schaaf Brittany K. Moore Robert M. Hicks Jay Achar Farhana Amanullah Pennan Barry Mercedes Becerra Domnica I. Chiotan Peter C. Drobac Jennifer Flood Jennifer Furin Medea Gegia Petros Isaakidis Andrei Mariandyshev Iveta Ozere N. Sarita Shah Alena Skrahina Elena Yablokova James A. Seddon Anneke C. Hesseling |
spellingShingle |
Muhammad Osman Elizabeth P. Harausz Anthony J. Garcia-Prats H. Simon Schaaf Brittany K. Moore Robert M. Hicks Jay Achar Farhana Amanullah Pennan Barry Mercedes Becerra Domnica I. Chiotan Peter C. Drobac Jennifer Flood Jennifer Furin Medea Gegia Petros Isaakidis Andrei Mariandyshev Iveta Ozere N. Sarita Shah Alena Skrahina Elena Yablokova James A. Seddon Anneke C. Hesseling Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis Emerging Infectious Diseases tuberculosis and other mycobacteria tuberculosis TB extensively drug-resistant tuberculosis XDR TB antimicrobial resistance |
author_facet |
Muhammad Osman Elizabeth P. Harausz Anthony J. Garcia-Prats H. Simon Schaaf Brittany K. Moore Robert M. Hicks Jay Achar Farhana Amanullah Pennan Barry Mercedes Becerra Domnica I. Chiotan Peter C. Drobac Jennifer Flood Jennifer Furin Medea Gegia Petros Isaakidis Andrei Mariandyshev Iveta Ozere N. Sarita Shah Alena Skrahina Elena Yablokova James A. Seddon Anneke C. Hesseling |
author_sort |
Muhammad Osman |
title |
Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis |
title_short |
Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis |
title_full |
Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis |
title_fullStr |
Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis |
title_full_unstemmed |
Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis |
title_sort |
treatment outcomes in global systematic review and patient meta-analysis of children with extensively drug-resistant tuberculosis |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2019-03-01 |
description |
Extensively drug-resistant tuberculosis (XDR TB) has extremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifestations, treatment, and outcomes for 37 children (<15 years of age) with bacteriologically confirmed XDR TB in 11 countries. These patients were managed during 1999–2013. For the 37 children, median age was 11 years, 32 (87%) had pulmonary TB, and 29 had a recorded HIV status; 7 (24%) were infected with HIV. Median treatment duration was 7.0 months for the intensive phase and 12.2 months for the continuation phase. Thirty (81%) children had favorable treatment outcomes. Four (11%) died, 1 (3%) failed treatment, and 2 (5%) did not complete treatment. We found a high proportion of favorable treatment outcomes among children, with mortality rates markedly lower than for adults. Regimens and duration of treatment varied considerably. Evaluation of new regimens in children is required. |
topic |
tuberculosis and other mycobacteria tuberculosis TB extensively drug-resistant tuberculosis XDR TB antimicrobial resistance |
url |
https://wwwnc.cdc.gov/eid/article/25/3/18-0852_article |
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